Abnormally Low Alanine Aminotransferase Ameliorated by a Living Donor Liver Transplantation: A Case Report

被引:0
|
作者
Omameuda, Takahiko [1 ]
Wakiya, Taiichi [1 ]
Sakuma, Yasunaru [1 ]
Onishi, Yasuharu [1 ]
Yamada, Toshiyuki [2 ]
Takanami, Katsutoshi [2 ]
Sanada, Yukihiro [1 ]
Hirata, Yuta [1 ]
Horiuchi, Toshio [1 ]
Sata, Naohiro [1 ]
机构
[1] Jichi Med Univ, Dept Surg, Div Gastroenterol Gen & Transplant Surg, 3311-1 Yakushiji, Shimotsuke, Tochigi 3290498, Japan
[2] Jichi Med Univ, Dept Clin Lab Med, Shimotsuke, Tochigi, Japan
关键词
PYRIDOXAL-PHOSPHATE; DEFICIENCY; PATIENT;
D O I
10.1016/j.transproceed.2024.04.025
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Alanine aminotransferase (ALT) is an enzyme that catalyzes the transfer of amino groups from alanine to ketoglutaric acid. ALT is an established marker of liver diseases. Occasionally, ALT levels may be abnormally low due to various factors, making accurate assessment difficult. To date, no studies have documented ALT alterations following Living donor liver transplantation (LDLT) in patients with low ALT levels. Here, we present a case of abnormally low ALT levels that were ameliorated by LDLT. A 27-year-old woman underwent LDLT for refractory cholangitis with biliary atresia. The patient's preoperative ALT level was 1 IU/L. Following graft reperfusion, ALT levels increased (peak value, 456 IU/L), primarily attributed to the donor liver. After LDLT, ALT levels consistently surpassed the lower limit. The differential diagnosis of abnormally low ALT levels suggested a genetic mutation as the most probable underlying cause. Even after LDLT, ALT levels in organs other than the transplanted liver would remain abnormally low. Therefore, to prevent underestimating liver damage, the standard ALT range for such cases should be set lower than the typical range.
引用
收藏
页码:1148 / 1152
页数:5
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