A scientific career from the early 1960s till 2023: A tale of the various protagonists

被引：1
|
作者：
De Clercq, Erik [1 ]
机构：
[1] Katholieke Univ Leuven, Rega Inst Med Res, Herestr 49, B-3000 Leuven, Belgium
来源：
BIOCHEMICAL PHARMACOLOGY | 2024年 / 228卷
关键词：
Interferon; NRTIs (Nucleoside reverse transcriptase; NtRTIs (Nucleotide reverse transcriptase; inhibitors); NNRTIs (Non-nucleoside reverse transcriptase; ANPs (acyclic nucleoside phosphonates); HUMAN-IMMUNODEFICIENCY-VIRUS; DOUBLE-STRANDED POLYRIBONUCLEOTIDE; ANTIVIRAL ACTIVITY; SELECTIVE-INHIBITION; HOST-RESISTANCE; HIGHLY POTENT; POLYMETHACRYLIC ACIDS; HYDROLASE INHIBITORS; INTERFERON INDUCTION; TOPICAL TREATMENT;
D O I：
10.1016/j.bcp.2024.116248
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
In this era spanning more than 60 years (from the early 1960s till today (2023), a broad variety of actors played a decisive role: Piet De Somer, Tom C. Merigan, Paul A. Janssen, Maurice Hilleman, and Georges Smets. Two protagonists (Antonin Hol & yacute; and John C. Martin) formed with me a unique triangle (the Hol & yacute; Trinity). Walter Fiers' group (with the help of Jean Content) contributed to the cloning of human beta-interferon, and Piet Herdewijn accomplished the chemical synthesis of an array of anti-HIV 2 ',3 '-dideoxynucleoside analogues. Rudi Pauwels, Masanori Baba, Dominique Schols, Johan Neyts, Lieve Naesens, Anita Van Lierde, Graciela Andrei, Robert Snoeck and Dirk Daelemans, as members of my team, helped me in achieving the intended goal, the development of a selective therapy for virus infections. The collaboration with "Lowie" (Guangdi Li) generated a new dimension for the future.
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页数：18
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