Oral intake of the microalgae Nannochloropsis oceanica, Chlorella vulgaris, or Phaeodactylum tricornutum improves metabolic conditions in hypercaloric-fed mice

被引：0

作者：

Kopp, Lena ^{[1
]}

Seethaler, Benjamin ^{[1
]}

Neumann, Ulrike ^{[1
]}

Bischoff, Stephan C. ^{[1
]}

机构：

[1] Univ Hohenheim, Inst Inst Nutr Med, Fruwirthstr 12, D-70593 Stuttgart, Germany

来源：

JOURNAL OF FUNCTIONAL FOODS | 2024年 / 121卷

关键词：

Microalgae; High-fat diet; Western style diet; Omega-3 fatty acids; Liver; Gut microbiome; EICOSAPENTAENOIC ACID; DIET; FUCOXANTHIN; ADIPOSE;

D O I：

10.1016/j.jff.2024.106429

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Diet-induced metabolic load is associated with excess body weight and liver steatosis. Here, selected microalgae, known to contain bioactive nutrients, were studied for beneficial metabolic effects in a mouse model of liver steatosis. Adult mice (8 per group) were fed either a Western-style diet (WSD) or a control diet +/- 15 % of the microalgae Chlorella vulgaris (CV), Nannochloropsis oceanica (NO), or Phaeodactylum tricornutum (PT) for 12 weeks. We evaluated liver fat content and liver damage, as well as fecal microbiota and lipopolysaccharide (LPS) translocation. NO supplementation to a WSD reduced the grade of liver steatosis (from 17 % to 4.7 %, p < 0.002), the liver damage score (p < 0.001), and LPS translocation (p < 0.001). PT had similar effects on liver damage score (p < 0.001) and LPS translocation (p < 0.001). CV supplementation reduced LPS translocation (p < 0.001). In conclusion, dietary supplementation of microalgae may be a novel sustainable approach to combat metabolic loads.

引用

页数：12