Design and Characterisation of Curcumin-Loaded Nanostructured Lipid Carriers for Safe and Efficient Topical Drug Delivery in The Treatment of Pressure Ulcer
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Shamsuddin, Nur amira mohd
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Univ Kebangsaan Malaysia, Fac Pharm, Ctr Drug Delivery Technol & Vaccine, Kuala Lumpur 50300, MalaysiaUniv Kebangsaan Malaysia, Fac Pharm, Ctr Drug Delivery Technol & Vaccine, Kuala Lumpur 50300, Malaysia
Shamsuddin, Nur amira mohd
[1
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Azmi, Fazren
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Univ Kebangsaan Malaysia, Fac Pharm, Ctr Drug Delivery Technol & Vaccine, Kuala Lumpur 50300, MalaysiaUniv Kebangsaan Malaysia, Fac Pharm, Ctr Drug Delivery Technol & Vaccine, Kuala Lumpur 50300, Malaysia
Azmi, Fazren
[1
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Husain, Khairana
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Univ Kebangsaan Malaysia, Fac Pharm, Ctr Drug & Herbal Dev, Kuala Lumpur 50300, MalaysiaUniv Kebangsaan Malaysia, Fac Pharm, Ctr Drug Delivery Technol & Vaccine, Kuala Lumpur 50300, Malaysia
Husain, Khairana
[2
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Mun, Leong lek
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Prima Nexus Sdn Bhd, 28-1B,Jalan Puteri 1-2, Puchong 47100, Selangor, MalaysiaUniv Kebangsaan Malaysia, Fac Pharm, Ctr Drug Delivery Technol & Vaccine, Kuala Lumpur 50300, Malaysia
Mun, Leong lek
[3
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Zulfakar, Mohd hanif
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Univ Kebangsaan Malaysia, Fac Pharm, Ctr Drug Delivery Technol & Vaccine, Kuala Lumpur 50300, MalaysiaUniv Kebangsaan Malaysia, Fac Pharm, Ctr Drug Delivery Technol & Vaccine, Kuala Lumpur 50300, Malaysia
Zulfakar, Mohd hanif
[1
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机构:
[1] Univ Kebangsaan Malaysia, Fac Pharm, Ctr Drug Delivery Technol & Vaccine, Kuala Lumpur 50300, Malaysia
[2] Univ Kebangsaan Malaysia, Fac Pharm, Ctr Drug & Herbal Dev, Kuala Lumpur 50300, Malaysia
[3] Prima Nexus Sdn Bhd, 28-1B,Jalan Puteri 1-2, Puchong 47100, Selangor, Malaysia
Pressure ulcers (PU) are chronic lesions with a high prevalence in at -risk populations. Although curcumin has various therapeutic properties, its use as a dermal therapeutic agent is limited by its poor solubility and permeability. This study aimed to develop nanostructured lipid carriers ( NLC s) to facilitate the topical use of curcumin as wound healing agent in treating PU . The optimised curcuminNLC s were characterised for their physicochemical properties, drug release, and skin permeation, while effectiveness and toxicity were investigated via cell viability, scratch assays, and an in vivo skin irritation test. The optimised curcuminNLC s comprised 3.5% solid lipids, 1% surfactant, and 2% co -surfactant with an average particle size of 134.68 +/- 6.0 nm, polydispersity index of 0.248 +/- 0.00, zeta potential of -44.94 +/- 5.44, percentage of encapsulation efficiency of 93.42 +/- 0.32%, and drug loading of 0.11 +/- 0.00%. CurcuminNLC s showed stable physicochemical properties and extended drug release for up to 48 h, with a cumulative release of 77.72% following a first -order kinetics. The formulation exhibited slower curcumin permeation than the free curcumin. Furthermore, the safe and non-toxic curcuminNLC s were highly effective at 0.98 mu M and showed a high rate of wound closure without skin irritation. Collectively, the NLC s developed for topical delivery of curcumin demonstrated prolonged and sustained release and improved wound healing activity, which indicates that curcuminNLC s are a viable strategy for treating PU.
机构:
Univ Mississippi, Sch Pharm, Dept Pharmaceut & Drug Delivery, Oxford, MS 38677 USA
Univ Mississippi, Res Inst Pharmaceut Sci, Oxford, MS 38677 USAUniv Mississippi, Sch Pharm, Dept Pharmaceut & Drug Delivery, Oxford, MS 38677 USA
Lakhani, Prit
Patil, Akash
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Univ Mississippi, Sch Pharm, Dept Pharmaceut & Drug Delivery, Oxford, MS 38677 USA
Univ Mississippi, Res Inst Pharmaceut Sci, Oxford, MS 38677 USAUniv Mississippi, Sch Pharm, Dept Pharmaceut & Drug Delivery, Oxford, MS 38677 USA
Patil, Akash
Taskar, Pranjal
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Univ Mississippi, Sch Pharm, Dept Pharmaceut & Drug Delivery, Oxford, MS 38677 USA
Univ Mississippi, Res Inst Pharmaceut Sci, Oxford, MS 38677 USAUniv Mississippi, Sch Pharm, Dept Pharmaceut & Drug Delivery, Oxford, MS 38677 USA
Taskar, Pranjal
Ashour, Eman
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Univ Mississippi, Sch Pharm, Dept Pharmaceut & Drug Delivery, Oxford, MS 38677 USAUniv Mississippi, Sch Pharm, Dept Pharmaceut & Drug Delivery, Oxford, MS 38677 USA
Ashour, Eman
Majumdar, Soumyajit
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Univ Mississippi, Sch Pharm, Dept Pharmaceut & Drug Delivery, Oxford, MS 38677 USA
Univ Mississippi, Res Inst Pharmaceut Sci, Oxford, MS 38677 USAUniv Mississippi, Sch Pharm, Dept Pharmaceut & Drug Delivery, Oxford, MS 38677 USA