Pathophysiology of human mitochondrial tRNA metabolism

被引：3
|
作者：
Zhang, Jian-Hui [1 ,2 ]
Eriani, Gilbert [3 ]
Zhou, Xiao-Long [1 ,2 ]
机构：
[1] Univ Chinese Acad Sci, Sch Life Sci, Hangzhou Inst Adv Study, Key Lab Syst Hlth Sci Zhejiang Prov, Hangzhou 310024, Peoples R China
[2] Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, Key Lab RNA Innovat Sci & Engn,CAS Ctr Excellence, 320 Yue Yang Rd, Shanghai 200031, Peoples R China
[3] Univ Strasbourg, Inst Biol Mol & Cellulaire, Architecture & React ARN, CNRS, 2 Allee Konrad Roentgen, F-67084 Strasbourg, France
来源：
TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2024年 / 35卷 / 04期
关键词：
D O I：
10.1016/j.tem.2024.01.002
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Mitochondria play multiple critical roles in cellular activity. In particular, mitochondrial translation is pivotal in the regulation of mitochondrial and cellular homeostasis. In this forum article, we discuss human mitochondrial tRNA metabolism and highlight its tight connection with various mitochondrial diseases caused by mutations in aminoacyltRNA synthetases, tRNAs, and tRNA-modifying enzymes.
引用
收藏
页码：285 / 289
页数：5
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