Optimal Parameters for Gastric Electrical Stimulation Therapy for Long-Term Symptom Control in Patients with Gastroparesis

被引:0
|
作者
Sarosiek, Irene [1 ]
Willauer, Alexandra N. [2 ]
Espino, Karina [1 ]
Sarosiek, Jerzy [1 ]
Galura, Gian [1 ]
Alvarado, Luis [3 ]
Dwivedi, Alok [3 ]
Davis, Brian [4 ]
Bashashati, Mohammad [5 ]
Mccallum, Richard W. [1 ]
机构
[1] Texas Tech Univ, Internal Med Dept, Hlth Sci Ctr El Paso, El Paso, TX 79905 USA
[2] Univ Cincinnati, Med Ctr, Dept Internal Med, Cincinnati, OH 45219 USA
[3] Texas Tech Univ, Hlth Sci Ctr, Dept Mol & Translat Med, Div Biostat & Epidemiol, El Paso, TX 79905 USA
[4] Texas Tech Univ, Surg Dept, Hlth Sci Ctr El Paso, El Paso, TX 79905 USA
[5] Univ Texas Austin, Dell Med Sch, Austin, TX 78723 USA
来源
GASTROINTESTINAL DISORDERS | 2024年 / 6卷 / 02期
关键词
gastroparesis; gastric emptying; electrical stimulation; GES parameters; diabetes mellitus; treatment outcome; nausea; vomiting; OUTCOMES;
D O I
10.3390/gidisord6020037
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background: Gastric electrical stimulation (GES) therapy is indicated for the treatment of drug-refractory gastroparesis (GP). However, the long-term effects of GES therapy on GP symptom control and identification of the optimal parameters to activate this long-term efficacy have not been investigated. Methods: We conducted a retrospective cohort analysis of 57 GP patients who received GES and pyloroplasty (PP). The interrogation of the GES system and assessment of GP symptoms were conducted at the initiation of GES therapy and during follow-up visits. We determined the changes in GES parameters including voltage (V), impedance (I), and current (C). The outcome was total symptom score (TSS), which was measured by self-reported GP symptoms. Results: The mean age of patients was 44 (+/- 14) years, and 72% were females. The etiology for GP was diabetes mellitus in 72% and idiopathic in 28%. The median duration of GES follow-up was 47 months (range 5-73) A significant decrease was found in individual symptom scores and the TSS (-10.8; 95%CI: -12.6, -9.08) compared to baseline scores (p < 0.0001). During follow-up, readings for I (515 vs. 598 ohm), V (3.3 vs. 4.8 V), and C (6.5 vs. 8.4 mA) significantly increased (p <= 0.0001 for all parameters). Higher GES settings were associated with lower TSS in the adjusted analysis (RC, -1.97; 95%CI: -3.81, -0.12, p = 0.037). Conclusions: these findings suggest that adjusting GES parameters over time based on optimizing symptom improvement should be incorporated into the long-term care of patients receiving gastric neurostimulation therapy.
引用
收藏
页码:538 / 548
页数:11
相关论文
共 50 条
  • [1] Optimal Parameters of Gastric Electrical Stimulation for Long-Term Symptom Control in Patients With Gastroparesis
    Willauer, Alexandra N.
    Espino, Karina
    Alvarado, Luis
    Dwivedi, Alok
    Siddiqui, Tariq S.
    McCallum, Richard
    Sarosiek, Irene
    [J]. AMERICAN JOURNAL OF GASTROENTEROLOGY, 2020, 115 : S666 - S666
  • [2] Both gastric electrical stimulation and pyloric surgery offer long-term symptom improvement in patients with gastroparesis
    Sarah Marowski
    Yiwei Xu
    Jake A. Greenberg
    Luke M. Funk
    Anne O. Lidor
    Amber L. Shada
    [J]. Surgical Endoscopy, 2021, 35 : 4794 - 4804
  • [3] Both gastric electrical stimulation and pyloric surgery offer long-term symptom improvement in patients with gastroparesis
    Marowski, Sarah
    Xu, Yiwei
    Greenberg, Jake A.
    Funk, Luke M.
    Lidor, Anne O.
    Shada, Amber L.
    [J]. SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, 2021, 35 (08): : 4794 - 4804
  • [4] Gastric Electrical Stimulation Improves Long-Term Outcomes of Patients with Gastroparesis
    Shafi, Mehnaz
    Hameed, Anam
    Qureshi, Waqar
    [J]. AMERICAN JOURNAL OF GASTROENTEROLOGY, 2013, 108 : S55 - S56
  • [5] Long-term outcomes of gastric electrical stimulation in children with gastroparesis
    Islam, Saleem
    McLaughlin, Jillian
    Pierson, Justine
    Jolley, Christopher
    Kedar, Archana
    Abell, Thomas
    [J]. JOURNAL OF PEDIATRIC SURGERY, 2016, 51 (01) : 67 - 71
  • [6] The Long-Term Efficacy and Safety of Pyloroplasty Combined with Gastric Electrical Stimulation Therapy in Gastroparesis
    Brian R. Davis
    Irene Sarosiek
    Mohammad Bashashati
    Ben Alvarado
    Richard W. McCallum
    [J]. Journal of Gastrointestinal Surgery, 2017, 21 : 222 - 227
  • [7] The Long-Term Efficacy and Safety of Pyloroplasty Combined with Gastric Electrical Stimulation Therapy in Gastroparesis
    Davis, Brian R.
    Sarosiek, Irene
    Bashashati, Mohammad
    Alvarado, Ben
    McCallum, Richard W.
    [J]. JOURNAL OF GASTROINTESTINAL SURGERY, 2017, 21 (02) : 222 - 227
  • [8] Is Gastric Electrical Stimulation (GES) a Long-Term Solution for Refractory Gastroparesis?
    Kordzadeh, Ali
    Askari, Alan
    Keppetiyagama, Chathuranga T.
    Clark, Jennifer
    Yazaki, Esturo
    Tang, Cheuk-Bong
    Kadirkamanathan, Sritharan S.
    [J]. GASTROENTEROLOGY, 2016, 150 (04) : S727 - S727
  • [9] Long-Term Follow-up of Gastric Electrical Stimulation Therapy and Pyloroplasty for Refractory Gastroparesis
    Mccallum, Richard
    Davis, Brian
    Sarosiek, Irene
    [J]. DIABETES, 2015, 64 : A339 - A340
  • [10] What Are the Optional Parameters of the Enterra Gastric Electrical Stimulation to Achieve Long Term Symptom Control in Gastroparetic Patients?
    Sarosiek, Irene
    Roeser, Kathy
    Forster, Jameson
    Lin, Zhiyue
    Sarosiek, Jerzy
    McCallum, Richard
    [J]. AMERICAN JOURNAL OF GASTROENTEROLOGY, 2009, 104 : S57 - S57