VISTA: A Novel Checkpoint for Cancer Immunotherapy

被引：1
|
作者：
Gao, Yu [1 ]
He, Yanting [2 ]
Tang, Yuanyuan [1 ]
Chen, Zhe-Sheng [4 ]
Qu, Meihua [1 ,3 ]
机构：
[1] Weifang Second Peoples Hosp, Translat Med Ctr, Weifang 261041, Shandong Provin, Peoples R China
[2] Qingdao Univ, Dept Pathol, Affiliated Hosp, Pingdu 266700, Shandong, Peoples R China
[3] Weifang Med Univ, Sch Life Sci & Technol, Weifang 261053, Peoples R China
[4] St Johns Univ, Coll Pharm & Hlth Sci, Dept Pharmaceut Sci, Queens, NY 11439 USA
来源：
DRUG DISCOVERY TODAY | 2024年 / 29卷 / 07期
关键词：
VISTA; immune checkpoint; immune regulatory proteins; tumor immunity; prognosis; IMMUNE-CHECKPOINT; T-CELLS; EXPRESSION; IPILIMUMAB; RECEPTOR; THERAPY; MOLECULE; PREVENTS; CTLA-4; DIES1;
D O I：
10.1016/j.drudis.2024.104045
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
V -domain Ig suppressor of T cell activation (VISTA) is a recently identified member of the B7 family of immunoregulatory proteins. It is pivotal for maintaining T cell quiescence and exerts a significant regulatory influence on the immune response to tumors. Accumulating clinical evidence suggests that the influence of VISTA on tumor immunity is more nuanced than initially postulated. Although these revelations add layers of complexity to our understanding of the function of VISTA, they also offer novel avenues for scientific inquiry and potential therapeutic targets. In this review, we scrutinize the current literature pertaining to the expression of VISTA in various of malignancies, aiming to elucidate its intricate roles within the tumor microenvironment and in cancer immunotherapy.
引用
收藏
页数：12
相关论文
共 50 条
  • [1] Immune Checkpoint Protein Vista as a Novel Target for Cancer Immunotherapy
    Wang, Li
    Noelle, Randolph
    LeMercier, Isabelle
    Lines, Janet
    Sergent, Petra
    [J]. JOURNAL OF IMMUNOTHERAPY, 2012, 35 (09) : 781 - 781
  • [2] VISTA Is a Novel Broad-Spectrum Negative Checkpoint Regulator for Cancer Immunotherapy
    Lines, J. Louise
    Sempere, Lorenzo F.
    Broughton, Thomas
    Wang, Li
    Noelle, Randolph
    [J]. CANCER IMMUNOLOGY RESEARCH, 2014, 2 (06) : 510 - 517
  • [3] Terminating Cancer by Blocking VISTA as a Novel Immunotherapy: Hasta la vista, baby
    Yum, Ji-Eun Irene
    Hong, Young-Kwon
    [J]. FRONTIERS IN ONCOLOGY, 2021, 11
  • [4] VISTA: A Promising Target for Cancer Immunotherapy?
    Tagliamento, Marco
    Agostinetto, Elisa
    Borea, Roberto
    Brandao, Mariana
    Poggio, Francesca
    Addeo, Alfredo
    Lambertini, Matteo
    [J]. IMMUNOTARGETS AND THERAPY, 2021, 10 : 185 - 200
  • [5] Expression of the immune checkpoint VISTA in breast cancer
    Zong, Liju
    Mo, Shengwei
    Yu, Shuangni
    Zhou, Yuncan
    Zhang, Ming
    Chen, Jie
    Xiang, Yang
    [J]. CANCER IMMUNOLOGY IMMUNOTHERAPY, 2020, 69 (08) : 1437 - 1446
  • [6] Expression of the immune checkpoint VISTA in breast cancer
    Liju Zong
    Shengwei Mo
    Shuangni Yu
    Yuncan Zhou
    Ming Zhang
    Jie Chen
    Yang Xiang
    [J]. Cancer Immunology, Immunotherapy, 2020, 69 : 1437 - 1446
  • [7] Expression of VISTA on tumor cells and its potential as a target of novel cancer immunotherapy
    Murat, Kumuruz
    Hamanishi, Junzo
    Matsumura, Noriomi
    Abiko, Kaoru
    Horikawa, Naoki
    Murakami, Ryusuke
    Yamaguchi, Ken
    Baba, Tsukasa
    Konishi, Ikuo
    Mandai, Masaki
    [J]. CANCER SCIENCE, 2018, 109 : 297 - 297
  • [8] Immune Checkpoint Inhibitors and Novel Immunotherapy Approaches for Breast Cancer
    Cejuela, Monica
    Vethencourt, Andrea
    Pernas, Sonia
    [J]. CURRENT ONCOLOGY REPORTS, 2022, 24 (12) : 1801 - 1819
  • [9] Immune Checkpoint Inhibitors and Novel Immunotherapy Approaches for Breast Cancer
    Mónica Cejuela
    Andrea Vethencourt
    Sonia Pernas
    [J]. Current Oncology Reports, 2022, 24 : 1801 - 1819
  • [10] Checkpoint blockade in cancer immunotherapy
    Korman, AJ
    Peggs, KS
    Allison, JP
    [J]. ADVANCES IN IMMUNOLOGY, VOL 90: CANCER IMMUNOTHERAPY, 2006, 90 : 297 - 339
12345