[1] Hosp Ramon & Cajal, Resp Dept, Madrid, Spain
[2] Inst Ramon y Cajal Invest Sanitaria IRYCIS, Madrid, Spain
[3] Hosp Puerta Hierro, Resp Dept, Madrid, Spain
[4] Aarhus Univ Hosp, Dept Anesthesiol & Intens Care, Aarhus, Denmark
[5] Aarhus Univ, Dept Clin Med, Aarhus, Denmark
[6] UCAM Univ Catolica San Antonio Murcia, Fac Hlth Sci, Chair Study Thromboembol Dis, Murcia, Spain
[7] CIBER Enfermedades Resp CIBERES, Madrid, Spain
[8] Harvard Med Sch, Brigham & Womens Hosp, Cardiovasc Med Div, Boston, MA USA
[9] Yale Univ, Sch Med, Ctr Outcomes Res & Evaluat CORE, New Haven, CT USA
[10] Cardiovasc Res Fdn, New York, NY USA
[11] Univ Alcala, Med Dept, Madrid, Spain