Clinical evaluation of therapeutic efficacy of a Siddha herbo mineral formulation "Kumaara Veeriya Kaantha Chenduram" with " Nellikkai Legiyam " (internal) in the treatment of Iron Deficiency Anemia

Kumaara Veeriya Kaantha Chenduram (KVKC) is a siddha herbomineral formulation indicated for paandu noi in Siddha literature. Paandu noi is a disease characterised by changes in the body's natural colour and pallor found in the skin, nails and conjunctiva. Objectives: To determine the efficacy of the KVKC , the open labeled clinical study was conducted in National Institute of Siddha OPD. Materials and Methods: The 30 patients with Iron deficiency anaemia were selected and treated with KVKC orally with the dose of 260 milligram twice in a day with Nellikai legiyam 6 gram continuously for 45 days. Laboratory investigations for haemoglobin was done on 1 st day and every 15 days once of the study. Results: Clinical assessment was done, based on the before and after treatment scores which were compared statistically and recorded. Regarding Haemoglobin level, 24(80%) patients showed increase of 1 to 3 grams from base level, 6(20%) patients showed increase of 0.1 to 0.9 grams from base level. Regarding Serum Ferritin, out of 30 patients, 9 (30%) patients showed 0.1-3.5ng/ml increase from its base level, 21 (70%) patients showed 3.6-7.0ng/ml increase from its base level.From the Statistical studies, the Mean +/- Standard deviation for Haemoglobin before treatment was 9.7 +/- 0.93 and after treatment was 11.18 +/- 1.08 which was statistically highly significant (p<0.0001).And Serum ferritin before treatment was 9.27 +/- 3.31, after treatment was 13.5 +/- 3.49 which was statistically significant (p<0.0001). Conclusion: It is concluded that Kumaara Veeriya Kaantha Chenduram is proved safe and clinically effective in treating Iron deficiency anaemia.