The Role of Inflammasomes in Heart Failure

被引：2

作者：

Vlachakis, Panayotis K. ^{[1
]}

Theofilis, Panagiotis ^{[1
]}

Kachrimanidis, Ioannis ^{[1
]}

Giannakopoulos, Konstantinos ^{[1
]}

Drakopoulou, Maria ^{[1
]}

Apostolos, Anastasios ^{[1
]}

Kordalis, Athanasios ^{[1
]}

Leontsinis, Ioannis ^{[1
]}

Tsioufis, Konstantinos ^{[1
]}

Tousoulis, Dimitris ^{[1
]}

机构：

[1] Natl & Kapodistrian Univ Athens, Hippokrat Gen Hosp, Dept Cardiol 1, Athens 11527, Greece

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 10期

关键词：

inflammasomes; heart failure; inflammation; biomarkers; therapeutic modulation; COLCHICINE; INFLAMMATION; INTERLEUKIN-1; ACTIVATION; PROTEIN; MCC950; RISK;

D O I：

10.3390/ijms25105372

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Heart failure (HF) poses a significant world health challenge due to the increase in the aging population and advancements in cardiac care. In the pathophysiology of HF, the inflammasome has been correlated with the development, progression, and complications of HF disease. Discovering biomarkers linked to inflammasomes enhances understanding of HF diagnosis and prognosis. Directing inflammasome signaling emerges as an innovative therapeutic strategy for managing HF. The present review aims to delve into this inflammatory cascade, understanding its role in the development of HF, its potential role as biomarker, as well as the prospects of modulating inflammasomes as a therapeutic approach for HF.

引用

页数：14

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