Disentangling the Individual-Shared and Individual-Specific Subspace of Altered Brain Functional Connectivity in Autism Spectrum Disorder

BACKGROUND: Despite considerable effort toward understanding the neural basis of autism spectrum disorder (ASD) using case -control analyses of resting -state functional magnetic resonance imaging data, findings are often not reproducible, largely due to biological and clinical heterogeneity among individuals with ASD. Thus, exploring the individual -shared and individual -specific altered functional connectivity (AFC) in ASD is important to understand this complex, heterogeneous disorder. METHODS: We considered 254 individuals with ASD and 295 typically developing individuals from the Autism Brain Imaging Data Exchange to explore the individual -shared and individual -specific subspaces of AFC. First, we computed AFC matrices of individuals with ASD compared with typically developing individuals. Then, common orthogonal basis extraction was used to project AFC of ASD onto 2 subspaces: an individual -shared subspace, which represents altered connectivity patterns shared across ASD, and an individual -specific subspace, which represents the remaining individual characteristics after eliminating the individual -shared altered connectivity patterns. RESULTS: Analysis yielded 3 common components spanning the individual -shared subspace. Common components were associated with differences of functional connectivity at the group level. AFC in the individual -specific subspace improved the prediction of clinical symptoms. The default mode network-related and cingulo-opercular network- related magnitudes of AFC in the individual -specific subspace were significantly correlated with symptom severity in social communication deficits and restricted, repetitive behaviors in ASD. CONCLUSIONS: Our study decomposed AFC of ASD into individual -shared and individual -specific subspaces, highlighting the importance of capturing and capitalizing on individual -specific brain connectivity features for dissecting heterogeneity. Our analysis framework provides a blueprint for parsing heterogeneity in other prevalent neurodevelopmental conditions.