Targeting Notch signaling pathways with natural bioactive compounds: a promising approach against cancer

被引:0
|
作者
Yang, Jia [1 ,2 ,3 ]
Sun, Qihui [1 ,4 ]
Liu, Xiaoyun [5 ]
Yang, Yong [5 ]
Rong, Rong [1 ,2 ]
Yan, Peiyu [2 ]
Xie, Ying [3 ]
机构
[1] Shandong Univ Tradit Chinese Med, Coll Pharm, Jinan, Shandong, Peoples R China
[2] Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Taipa, Macao, Peoples R China
[3] Guangzhou Univ Chinese Med, Affiliated Hosp 2, State Key Lab Tradit Chinese Med Syndrome, Guangzhou, Peoples R China
[4] Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing, Peoples R China
[5] Shandong Univ Tradit Chinese Med, Key Lab Tradit Chinese Med Class Theory, Minist Educ, Jinan, Shandong, Peoples R China
基金
中国国家自然科学基金;
关键词
notch signaling; crosstalk; oncogenic pathways; phytochemicals; cancer; KAPPA-B ACTIVITY; CELL-GROWTH INHIBITION; BREAST-CANCER; DOWN-REGULATION; COLORECTAL-CANCER; THERAPEUTIC TARGET; FACTOR RECEPTOR; WITHAFERIN-A; STEM-CELLS; IN-VITRO;
D O I
10.3389/fphar.2024.1412669
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Notch signaling pathway is activated abnormally in solid and hematological tumors, which perform essential functions in cell differentiation, survival, proliferation, and angiogenesis. The activation of Notch signaling and communication among Notch and other oncogenic pathways heighten malignancy aggressiveness. Thus, targeting Notch signaling offers opportunities for improved survival and reduced disease incidence. Already, most attention has been given to its role in the cancer cells. Recent research shows that natural bioactive compounds can change signaling molecules that are linked to or interact with the Notch pathways. This suggests that there may be a link between Notch activation and the growth of tumors. Here, we sum up the natural bioactive compounds that possess inhibitory effects on human cancers by impeding the Notch pathway and preventing Notch crosstalk with other oncogenic pathways, which provoke further study of these natural products to derive rational therapeutic regimens for the treatment of cancer and develop novel anticancer drugs. This review revealed Notch as a highly challenging but promising target in oncology.
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页数:17
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