Machine Learning-Based Predictive Models for Patients with Venous Thromboembolism: A Systematic Review

被引:1
|
作者
Danilatou, Vasiliki [1 ,2 ,6 ]
Dimopoulos, Dimitrios [3 ]
Kostoulas, Theodoros [3 ]
Douketis, James [4 ,5 ]
机构
[1] European Univ Cyprus, Sch Med, Nicosia, Cyprus
[2] Sphynx Technol Solut, Healthcare Div, Nicosia, Cyprus
[3] Univ Aegean, Sch Engn, Dept Informat & Commun Syst Engn, North Aegean, Greece
[4] McMaster Univ, Dept Med, Hamilton, ON, Canada
[5] St Josephs Healthcare, Dept Med, Hamilton, ON, Canada
[6] European Univ Cyprus, Nicosia, Cyprus
关键词
machine learning; artificial intelligence; venous thromboembolism; electronic health record; clinical prediction models; SUSPECTED PULMONARY-EMBOLISM; ARTIFICIAL-INTELLIGENCE; EMERGENCY-DEPARTMENT; PRETEST PROBABILITY; MEDICAL PATIENTS; CLINICAL-MODEL; D-DIMER; RISK; HEALTH; THROMBOSIS;
D O I
10.1055/a-2299-4758
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background Venous thromboembolism (VTE) is a chronic disorder with a significant health and economic burden. Several VTE-specific clinical prediction models (CPMs) have been used to assist physicians in decision-making but have several limitations. This systematic review explores if machine learning (ML) can enhance CPMs by analyzing extensive patient data derived from electronic health records. We aimed to explore ML-CPMs' applications in VTE for risk stratification, outcome prediction, diagnosis, and treatment. Methods Three databases were searched: PubMed, Google Scholar, and IEEE electronic library. Inclusion criteria focused on studies using structured data, excluding non-English publications, studies on non-humans, and certain data types such as natural language processing and image processing. Studies involving pregnant women, cancer patients, and children were also excluded. After excluding irrelevant studies, a total of 77 studies were included. Results Most studies report that ML-CPMs outperformed traditional CPMs in terms of receiver operating area under the curve in the four clinical domains that were explored. However, the majority of the studies were retrospective, monocentric, and lacked detailed model architecture description and external validation, which are essential for quality audit. This review identified research gaps and highlighted challenges related to standardized reporting, reproducibility, and model comparison. Conclusion ML-CPMs show promise in improving risk assessment and individualized treatment recommendations in VTE. Apparently, there is an urgent need for standardized reporting and methodology for ML models, external validation, prospective and real-world data studies, as well as interventional studies to evaluate the impact of artificial intelligence in VTE.
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页数:13
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