Estrogenic and Anti-estrogenic Constituents of Erythrina caffra

被引：0
|
作者：
Hsu, Yu-Ming [1 ]
Lai, Wan-Chun [1 ]
Li, Chi-Ying [1 ]
Lan, Yu-Hsuan [2 ]
Tsai, Yu-Chi [1 ]
Hunyadi, Attila [3 ]
Hou, Ming-Feng [4 ,5 ]
Yuan, Shyng-Shiou [4 ,6 ]
Wu, Yang-Chang [2 ,7 ,8 ,9 ]
Chang, Fang-Rong [1 ,4 ,10 ,11 ,12 ]
机构：
[1] Kaohsiung Med Univ, Grad Inst Nat Prod, Coll Pharm, Kaohsiung 807, Taiwan
[2] China Med Univ, Sch Pharm, Coll Pharm, Taichung 404, Taiwan
[3] Univ Szeged, Inst Pharmacognosy, H-6720 Szeged, Hungary
[4] Kaohsiung Med Univ Hosp, Ctr Canc, Kaohsiung 807, Taiwan
[5] Kaohsiung Med Univ, Kaohsiung Municipal Hsiao Kang Hosp, Kaohsiung 807, Taiwan
[6] Kaohsiung Med Univ Hosp, Translat Res Ctr, Kaohsiung 807, Taiwan
[7] China Med Univ, Res Ctr Chinese Herbal Med, Taichung 404, Taiwan
[8] China Med Univ Hosp, Chinese Med Res & Dev Ctr, Taichung 404, Taiwan
[9] China Med Univ Hosp, Ctr Mol Med, Taichung 404, Taiwan
[10] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 804, Taiwan
[11] Kaohsiung Med Univ, Res Ctr Environm Med, Kaohsiung 807, Taiwan
[12] Kaohsiung Med Univ, Ctr Infect Dis & Canc Res, Kaohsiung 807, Taiwan
来源：
NATURAL PRODUCT COMMUNICATIONS | 2016年 / 11卷 / 08期
关键词：
Erythrina caffra; Erythrina; Phytoestrogen; SERM; Erycaffrain A; TUMOR-CELL-LINES; LIRIOPE-PLATYPHYLLA; PHYTOESTROGENS; ROOTS; ISOFLAVONES; VERSATILE; SYSTEM; ASSAY;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Utilizing the pER8:GUS transgenic plant bioassay system to monitor estrogenic activity-guided fractionation, one new constituent, erycaffrain A, together with 11 known compounds were isolated from the ethanolic extract of Erythrina caffra. The structures of the isolated compounds were identified in combination with spectroscopic analyses. This is the first study reporting the estrogenic activity of E caffra. The new compound exhibited as a SREM, but also showed both estrogenic and anti-estrogenic activities in the MCF-7 cancer cell model. Several known phytoestrogens in this plant also revealed possible new functions for E. caffra stem.
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收藏
页码：1099 / 1102
页数：4
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