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OKI-219 is an inhibitor of PI3K α H1047R that has brain penetrance and anti-tumor activity in a preclinical intracranial model of metastatic breast cancer
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作者
:
Strait, Alexander A.
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0
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Strait, Alexander A.
Taylor, Molly A.
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0
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0
h-index:
0
Taylor, Molly A.
Litwiler, Kevin S.
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0
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0
h-index:
0
Litwiler, Kevin S.
Zhao, Qian
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0
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0
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0
Zhao, Qian
Mareska, David A.
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0
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0
h-index:
0
Mareska, David A.
Boys, Mark L.
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0
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0
h-index:
0
Boys, Mark L.
Izrayelit, Yevgeniy
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0
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0
h-index:
0
Izrayelit, Yevgeniy
Woessner, Richard
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0
引用数:
0
h-index:
0
Woessner, Richard
Winkler, James D.
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0
引用数:
0
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0
Winkler, James D.
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:
CANCER RESEARCH
|
2024年
/ 84卷
/ 07期
关键词
:
D O I
:
10.1158/1538-7445.AM2024-LB174
中图分类号
:
R73 [肿瘤学];
学科分类号
:
100214 ;
摘要
:
LB174
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页数:2
相关论文
共 30 条
[1]
Discovery and characterization of OKI-219, an orally bioavailable H1047R-mutant-selective inhibitor of PI3Kα
Taylor, Molly A.
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0
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0
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0
Taylor, Molly A.
Zhao, Qian
论文数:
0
引用数:
0
h-index:
0
Zhao, Qian
Mareska, David
论文数:
0
引用数:
0
h-index:
0
Mareska, David
Hoh, Maria
论文数:
0
引用数:
0
h-index:
0
Hoh, Maria
Izrayelit, Yevgeniy
论文数:
0
引用数:
0
h-index:
0
Izrayelit, Yevgeniy
Litwiler, Kevin
论文数:
0
引用数:
0
h-index:
0
Litwiler, Kevin
Boys, Mark L.
论文数:
0
引用数:
0
h-index:
0
Boys, Mark L.
Woessner, Rich
论文数:
0
引用数:
0
h-index:
0
Woessner, Rich
Walker, Duncan
论文数:
0
引用数:
0
h-index:
0
Walker, Duncan
Diamond, Jennifer
论文数:
0
引用数:
0
h-index:
0
Diamond, Jennifer
Winkler, James D.
论文数:
0
引用数:
0
h-index:
0
Winkler, James D.
[J].
MOLECULAR CANCER THERAPEUTICS,
2023,
22
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[2]
LOXO-783: A potent, highly mutant selective and brain-penetrant allosteric PI3Kα H1047R inhibitor in combination with standard of care (SOC) treatments in preclinical PI3Kα H1047R-mutant breast cancer models
Puca, Loredana
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0
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0
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0
Puca, Loredana
Dowless, Michele S.
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0
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0
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0
Dowless, Michele S.
Perez-Ferreiro, Carmen M.
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0
Perez-Ferreiro, Carmen M.
Ortiz-Ruiz, Maria Jesus
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0
Ortiz-Ruiz, Maria Jesus
Donoho, Gregory P.
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Donoho, Gregory P.
Capen, Andrew
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Capen, Andrew
Huber, Lysiane
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Huber, Lysiane
Bogner, Sarah M.
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Bogner, Sarah M.
Fei, Dongling
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0
Fei, Dongling
Manro, Jason R.
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Manro, Jason R.
Yu, Chun Ping
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0
Yu, Chun Ping
Xu, Wei Guo
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Xu, Wei Guo
Wang, Rui
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Wang, Rui
Chen, Shuang
论文数:
0
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Chen, Shuang
Hicks, Mark A.
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h-index:
0
Hicks, Mark A.
Zolfaghari, Parisa
论文数:
0
引用数:
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h-index:
0
Zolfaghari, Parisa
Faber, Andrew
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引用数:
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Faber, Andrew
Gilmour, Raymond
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引用数:
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h-index:
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Gilmour, Raymond
Ramstetter, Monica D.
论文数:
0
引用数:
0
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0
Ramstetter, Monica D.
Chang, Matthew T.
论文数:
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0
Chang, Matthew T.
Lallena, Maria Jose
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Lallena, Maria Jose
Gong, Xuequian
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Gong, Xuequian
Hyman, David M.
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Hyman, David M.
Smyth, Lillian M.
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Smyth, Lillian M.
Brandhuber, Barbara J.
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0
Brandhuber, Barbara J.
Taylor, Barry S.
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Taylor, Barry S.
Klippel, Anke
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Klippel, Anke
[J].
CANCER RESEARCH,
2023,
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[3]
OKI-219, a PI3KaH1047R-mutant-selective inhibitor demonstrates efficacy as a single agent and drives combination responses with standard of care therapies in preclinical PI3KaH1047R mutant breast cancer models
Taylor, Molly A.
论文数:
0
引用数:
0
h-index:
0
Taylor, Molly A.
Zhao, Qian
论文数:
0
引用数:
0
h-index:
0
Zhao, Qian
Mareska, David
论文数:
0
引用数:
0
h-index:
0
Mareska, David
Hoh, Maria
论文数:
0
引用数:
0
h-index:
0
Hoh, Maria
Izrayelit, Yevgeniy
论文数:
0
引用数:
0
h-index:
0
Izrayelit, Yevgeniy
Litwiler, Kevin
论文数:
0
引用数:
0
h-index:
0
Litwiler, Kevin
Boys, Mark L.
论文数:
0
引用数:
0
h-index:
0
Boys, Mark L.
Woessner, Rich
论文数:
0
引用数:
0
h-index:
0
Woessner, Rich
Walker, Duncan
论文数:
0
引用数:
0
h-index:
0
Walker, Duncan
Winkler, James D.
论文数:
0
引用数:
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Winkler, James D.
Diamond, Jennifer
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Diamond, Jennifer
[J].
CANCER RESEARCH,
2024,
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[4]
Physiological expression of PI3K H1047R mutation reveals its anti-metastatic potential in ErbB2-driven breast cancer
Simond, Alexandra M.
论文数:
0
引用数:
0
h-index:
0
机构:
McGill Univ, Rosalind & Morris Goodman Canc Res Inst, Montreal, PQ, Canada
McGill Univ, Dept Biochem, Montreal, PQ, Canada
McGill Univ, Rosalind & Morris Goodman Canc Res Inst, Montreal, PQ, Canada
Simond, Alexandra M.
Bui, Tung
论文数:
0
引用数:
0
h-index:
0
机构:
McGill Univ, Rosalind & Morris Goodman Canc Res Inst, Montreal, PQ, Canada
McGill Univ, Dept Biochem, Montreal, PQ, Canada
McGill Univ, Rosalind & Morris Goodman Canc Res Inst, Montreal, PQ, Canada
Bui, Tung
Zuo, Dongmei
论文数:
0
引用数:
0
h-index:
0
机构:
McGill Univ, Rosalind & Morris Goodman Canc Res Inst, Montreal, PQ, Canada
McGill Univ, Rosalind & Morris Goodman Canc Res Inst, Montreal, PQ, Canada
Zuo, Dongmei
Sanguin-Gendreau, Virginie
论文数:
0
引用数:
0
h-index:
0
机构:
McGill Univ, Rosalind & Morris Goodman Canc Res Inst, Montreal, PQ, Canada
McGill Univ, Rosalind & Morris Goodman Canc Res Inst, Montreal, PQ, Canada
Sanguin-Gendreau, Virginie
Rao, Trisha
论文数:
0
引用数:
0
h-index:
0
机构:
McGill Univ, Rosalind & Morris Goodman Canc Res Inst, Montreal, PQ, Canada
McGill Univ, Rosalind & Morris Goodman Canc Res Inst, Montreal, PQ, Canada
Rao, Trisha
Phillips, Wayne A.
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0
引用数:
0
h-index:
0
机构:
Peter MacCallum Canc Ctr, Melbourne, Vic, Australia
Univ Melbourne, Sir Peter MacCallum Dept Oncol, Melbourne, Vic, Australia
McGill Univ, Rosalind & Morris Goodman Canc Res Inst, Montreal, PQ, Canada
Phillips, Wayne A.
Cardiff, Robert D.
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Calif Davis, Ctr Comparat Med, Davis, CA 95616 USA
McGill Univ, Rosalind & Morris Goodman Canc Res Inst, Montreal, PQ, Canada
Cardiff, Robert D.
Muller, William J.
论文数:
0
引用数:
0
h-index:
0
机构:
McGill Univ, Rosalind & Morris Goodman Canc Res Inst, Montreal, PQ, Canada
McGill Univ, Dept Biochem, Montreal, PQ, Canada
McGill Univ, Fac Med, Montreal, PQ, Canada
McGill Univ, Rosalind & Morris Goodman Canc Res Inst, Montreal, PQ, Canada
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Physiological expression of PI3K H1047R mutation reveals its anti-metastatic potential in ErbB2-driven breast cancer
Alexandra M. Simond
论文数:
0
引用数:
0
h-index:
0
机构:
McGill University,Rosalind and Morris Goodman Cancer Research Institute
Alexandra M. Simond
Tung Bui
论文数:
0
引用数:
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机构:
McGill University,Rosalind and Morris Goodman Cancer Research Institute
Tung Bui
Dongmei Zuo
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机构:
McGill University,Rosalind and Morris Goodman Cancer Research Institute
Dongmei Zuo
Virginie Sanguin-Gendreau
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机构:
McGill University,Rosalind and Morris Goodman Cancer Research Institute
Virginie Sanguin-Gendreau
Trisha Rao
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0
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h-index:
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机构:
McGill University,Rosalind and Morris Goodman Cancer Research Institute
Trisha Rao
Wayne A. Phillips
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机构:
McGill University,Rosalind and Morris Goodman Cancer Research Institute
Wayne A. Phillips
Robert D. Cardiff
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0
引用数:
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机构:
McGill University,Rosalind and Morris Goodman Cancer Research Institute
Robert D. Cardiff
William J. Muller
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Preclinical characterization of LOX-22783, a highly potent, mutant-selective and brain-penetrant allosteric PI3Kα H1047R inhibitor
Klippel, Anke
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Klippel, Anke
Wang, Rui
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Puca, Loredana
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Zolfaghari, Parisa
Hicks, Mark, II
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Hicks, Mark, II
Callies, Sophie
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Callies, Sophie
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Mattioni, Brian
LeBrun, Laurie
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LeBrun, Laurie
Durbin, Jim
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Durbin, Jim
Anderson, Erin
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Mayne, Chris
Kesicki, Edward
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Kesicki, Edward
Kolakowski, Gabrielle
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Kolakowski, Gabrielle
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Discovery of HP567, a highly potent, brain-penetrating, and H1047R-selective PI3K α inhibitor for the treatment of tumors bearing H1047R mutation
Li, Jing
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Li, Jing
Fan, Lei
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Liu, Chengcheng
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Yanbian Univ, Coll Med, Dept Pathol, Yanji 133002, Peoples R China
Yanbian Univ, Coll Med, Canc Res Ctr, Yanji 133002, Peoples R China
Yanbian Univ, Coll Med, Dept Biochem & Mol Biol, Yanji 133002, Peoples R China
Yanbian Univ, Coll Med, Dept Pathol, Yanji 133002, Peoples R China
Chen, Liyan
Jin, Tiefeng
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Yanbian Univ, Coll Med, Dept Pathol, Yanji 133002, Peoples R China
Yanbian Univ, Coll Med, Canc Res Ctr, Yanji 133002, Peoples R China
Yanbian Univ, Coll Med, Dept Pathol, Yanji 133002, Peoples R China
Jin, Tiefeng
Zhu, Kun
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Yanbian Univ, Coll Med, Dept Biochem & Mol Biol, Yanji 133002, Peoples R China
Yanbian Univ, Coll Med, Dept Pathol, Yanji 133002, Peoples R China
Zhu, Kun
Piao, Yingshi
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机构:
Yanbian Univ, Coll Med, Dept Pathol, Yanji 133002, Peoples R China
Yanbian Univ, Coll Med, Canc Res Ctr, Yanji 133002, Peoples R China
Yanbian Univ, Coll Med, Dept Pathol, Yanji 133002, Peoples R China
Piao, Yingshi
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引用数:
h-index:
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Quan, Taihao
Quan, Chunji
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机构:
Yanbian Univ, Coll Med, Dept Pathol, Yanji 133002, Peoples R China
Yanbian Univ, Coll Med, Canc Res Ctr, Yanji 133002, Peoples R China
Yanbian Univ, Coll Med, Dept Pathol, Yanji 133002, Peoples R China
Quan, Chunji
Lin, Zhenhua
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机构:
Yanbian Univ, Coll Med, Dept Pathol, Yanji 133002, Peoples R China
Yanbian Univ, Coll Med, Canc Res Ctr, Yanji 133002, Peoples R China
Yanbian Univ, Coll Med, Dept Pathol, Yanji 133002, Peoples R China
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0
机构:
Univ Hosp Leuven, Expt Oncol Lab, Louvain, Belgium
Univ Hosp Leuven, Expt Oncol Lab, Louvain, Belgium
Schoffski, Patrick
Cresta, Sara
论文数:
0
引用数:
0
h-index:
0
机构:
Fdn IRCCS Inst Nazl Tumori, Milan, Italy
Univ Hosp Leuven, Expt Oncol Lab, Louvain, Belgium
Cresta, Sara
Mayer, Ingrid A.
论文数:
0
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0
h-index:
0
机构:
Vanderbilt Ingram Canc Ctr, Springfield, TN USA
Univ Hosp Leuven, Expt Oncol Lab, Louvain, Belgium
Mayer, Ingrid A.
Wildiers, Hans
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0
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0
h-index:
0
机构:
Univ Hosp Leuven, Expt Oncol Lab, Louvain, Belgium
Univ Hosp Leuven, Expt Oncol Lab, Louvain, Belgium
Wildiers, Hans
Rooney, Isabelle
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0
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0
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Genentech Inc, Exploratory Clin Dev, San Francisco, CA USA
Univ Hosp Leuven, Expt Oncol Lab, Louvain, Belgium
Rooney, Isabelle
Apt, Doris
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0
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0
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0
机构:
Genentech Inc, Exploratory Clin Dev, San Francisco, CA USA
Univ Hosp Leuven, Expt Oncol Lab, Louvain, Belgium
Apt, Doris
Gendreau, Steve
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0
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Genentech Inc, Exploratory Clin Dev, San Francisco, CA USA
Univ Hosp Leuven, Expt Oncol Lab, Louvain, Belgium
Gendreau, Steve
Morrissey, Kari
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0
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0
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0
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Genentech Inc, Small Mol Clin Pharmacol, San Francisco, CA USA
Univ Hosp Leuven, Expt Oncol Lab, Louvain, Belgium
Morrissey, Kari
Lackner, Mark
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0
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0
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0
机构:
Genentech Inc, Oncol Biomarker Dev, San Francisco, CA USA
Univ Hosp Leuven, Expt Oncol Lab, Louvain, Belgium
Lackner, Mark
Spoerke, Jill
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0
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0
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Genentech Inc, Exploratory Clin Dev, San Francisco, CA USA
Univ Hosp Leuven, Expt Oncol Lab, Louvain, Belgium
Spoerke, Jill
Winer, Eric
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0
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机构:
Dana Farber Canc Inst, Boston, MA USA
Univ Hosp Leuven, Expt Oncol Lab, Louvain, Belgium
Winer, Eric
[J].
CANCER RESEARCH,
2015,
75
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