breast cancer;
young women;
postpartum;
involution;
liquid biopsy;
molecular diagnostics;
early detection;
FLUID SHEAR-STRESS;
MAMMARY-GLAND INVOLUTION;
PATHOLOGICAL CHARACTERISTICS;
DIAGNOSTIC PERFORMANCE;
EPITHELIAL-CELLS;
WORSE PROGNOSIS;
GENE-EXPRESSION;
SEX-HORMONES;
TUMOR SIZE;
HIGH-RISK;
D O I:
10.3389/fonc.2024.1398196
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
Young onset breast cancer (YOBC) is an increasing demographic with unique biology, limited screening, and poor outcomes. Further, women with postpartum breast cancers (PPBCs), cancers occurring up to 10 years after childbirth, have worse outcomes than other young breast cancer patients matched for tumor stage and subtype. Early-stage detection of YOBC is critical for improving outcomes. However, most young women (under 45) do not meet current age guidelines for routine mammographic screening and are thus an underserved population. Other challenges to early detection in this population include reduced performance of standard of care mammography and reduced awareness. Women often face significant barriers in accessing health care during the postpartum period and disadvantaged communities face compounding barriers due to systemic health care inequities. Blood tests and liquid biopsies targeting early detection may provide an attractive option to help address these challenges. Test development in this area includes understanding of the unique biology involved in YOBC and in particular PPBCs that tend to be more aggressive and deadly. In this review, we will present the status of breast cancer screening and detection in young women, provide a summary of some unique biological features of YOBC, and discuss the potential for blood tests and liquid biopsy platforms to address current shortcomings in timely, equitable detection.
机构:
Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 USA
Magbanua, Mark Jesus M.
Gumusay, Ozge
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Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 USA
Gumusay, Ozge
Kurzrock, Razelle
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Worldwide Innovat Network WIN Personalized Canc T, Villejuif, FranceUniv Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 USA
Kurzrock, Razelle
van't Veer, Laura J.
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Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 USA
van't Veer, Laura J.
Rugo, Hope S.
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机构:
Univ Calif San Francisco, Div Hematol Oncol, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 USA
机构:
Chinese Acad Med Sci, Canc Hosp,Shanxi Med Univ, Shanxi Prov Canc Hosp, Shanxi Hosp, Taiyuan, Peoples R ChinaChinese Acad Med Sci, Canc Hosp,Shanxi Med Univ, Shanxi Prov Canc Hosp, Shanxi Hosp, Taiyuan, Peoples R China
Liu, Xiangrong
Papukashvili, Dimitri
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Southern Univ Sci & Technol, Sch Med, Dept Pharmacol, Shenzhen, Peoples R ChinaChinese Acad Med Sci, Canc Hosp,Shanxi Med Univ, Shanxi Prov Canc Hosp, Shanxi Hosp, Taiyuan, Peoples R China
Papukashvili, Dimitri
Wang, Zhixiang
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Chinese Acad Med Sci, Canc Hosp,Shanxi Med Univ, Shanxi Prov Canc Hosp, Shanxi Hosp, Taiyuan, Peoples R ChinaChinese Acad Med Sci, Canc Hosp,Shanxi Med Univ, Shanxi Prov Canc Hosp, Shanxi Hosp, Taiyuan, Peoples R China
Wang, Zhixiang
Liu, Yan
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Chinese Acad Med Sci, Canc Hosp,Shanxi Med Univ, Shanxi Prov Canc Hosp, Shanxi Hosp, Taiyuan, Peoples R ChinaChinese Acad Med Sci, Canc Hosp,Shanxi Med Univ, Shanxi Prov Canc Hosp, Shanxi Hosp, Taiyuan, Peoples R China
Liu, Yan
Chen, Xiaoxia
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Chinese Acad Med Sci, Canc Hosp,Shanxi Med Univ, Shanxi Prov Canc Hosp, Shanxi Hosp, Taiyuan, Peoples R ChinaChinese Acad Med Sci, Canc Hosp,Shanxi Med Univ, Shanxi Prov Canc Hosp, Shanxi Hosp, Taiyuan, Peoples R China
Chen, Xiaoxia
Li, Jianrong
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Chinese Acad Med Sci, Canc Hosp,Shanxi Med Univ, Shanxi Prov Canc Hosp, Shanxi Hosp, Taiyuan, Peoples R ChinaChinese Acad Med Sci, Canc Hosp,Shanxi Med Univ, Shanxi Prov Canc Hosp, Shanxi Hosp, Taiyuan, Peoples R China
Li, Jianrong
Li, Zhiyuan
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Chinese Acad Med Sci, Canc Hosp,Shanxi Med Univ, Shanxi Prov Canc Hosp, Shanxi Hosp, Taiyuan, Peoples R ChinaChinese Acad Med Sci, Canc Hosp,Shanxi Med Univ, Shanxi Prov Canc Hosp, Shanxi Hosp, Taiyuan, Peoples R China
Li, Zhiyuan
Hu, Linjie
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Chinese Acad Med Sci, Canc Hosp,Shanxi Med Univ, Shanxi Prov Canc Hosp, Shanxi Hosp, Taiyuan, Peoples R ChinaChinese Acad Med Sci, Canc Hosp,Shanxi Med Univ, Shanxi Prov Canc Hosp, Shanxi Hosp, Taiyuan, Peoples R China
Hu, Linjie
Li, Zheng
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Chinese Acad Med Sci, Canc Hosp,Shanxi Med Univ, Shanxi Prov Canc Hosp, Shanxi Hosp, Taiyuan, Peoples R ChinaChinese Acad Med Sci, Canc Hosp,Shanxi Med Univ, Shanxi Prov Canc Hosp, Shanxi Hosp, Taiyuan, Peoples R China
Li, Zheng
Rcheulishvili, Nino
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Southern Univ Sci & Technol, Sch Med, Dept Pharmacol, Shenzhen, Peoples R ChinaChinese Acad Med Sci, Canc Hosp,Shanxi Med Univ, Shanxi Prov Canc Hosp, Shanxi Hosp, Taiyuan, Peoples R China
Rcheulishvili, Nino
Lu, Xiaoqing
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Chinese Acad Med Sci, Canc Hosp,Shanxi Med Univ, Shanxi Prov Canc Hosp, Shanxi Hosp, Taiyuan, Peoples R ChinaChinese Acad Med Sci, Canc Hosp,Shanxi Med Univ, Shanxi Prov Canc Hosp, Shanxi Hosp, Taiyuan, Peoples R China
Lu, Xiaoqing
Ma, Jinfeng
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机构:
Chinese Acad Med Sci, Canc Hosp,Shanxi Med Univ, Shanxi Prov Canc Hosp, Shanxi Hosp, Taiyuan, Peoples R ChinaChinese Acad Med Sci, Canc Hosp,Shanxi Med Univ, Shanxi Prov Canc Hosp, Shanxi Hosp, Taiyuan, Peoples R China