Comparative evaluation of titanium-prepared platelet-rich fibrin with and without herbal extract: a histological study

Uvod/Cilj. Ubrizgavanje biljnog ekstrakta u koncentrat trombocita jedan je od novijih protokola le & ccaron;enja, koji omogu & cacute;ava da koncentrat trombocita deluje kao sistem za kontinuiranu isporuku lekova. Analiza histolo & scaron;kih preseka titanijumom- pripremljenog fibrina oboga & cacute;enog trombocitima ( titanium-prepared platelet-rich fibrin - T-PRF) u koji je ubrizgan biljni ekstrakt, mogla bi biti korisna za procenu izgleda (obrasca) i promena strukture T-PRF. Cilj rada bio je da se proceni izgled fi brinske mre & zcaron;e, celularnost i grani & ccaron;no podru & ccaron;je fibrina samog T-PRF i T-PRF u koji je ubrizgan biljni ekstrakt. Metode. Od 10 mL krvi svakog statistical significance was found among the studied groups (p = 0.172). A statistically significant difference was shown in the packeting (p = 0.018) and layered (p = 0.028) patterns of the fibrin network, and there was no statistically significant difference in the scattered (p p = 0.749) pattern among the examined groups. Cellularity and cell pattern values were not statistically significantly different for both groups (p p = 1.00, p = 0.3111, respectively). Moreover, the values determined for red blood cells, white blood cells, and platelets were not statistically significantly different (p p = 0.147), as well as for the fibrin border area between cells and meshwork (p = 0.206). Conclusion. The obtained results could be useful for the development of a new treatment strategy in dentistry, by utilizing T-PRF with incorporated herbal extracts or antibiotics, as a local sustained DD system.