Oral Exposure to Low Concentration of Fumonisin B2, but Not Fumonisin B1, Significantly Exacerbates the Pathophysiology of Imiquimod-Induced Psoriasis in Mice

被引:0
|
作者
Ando, Mana [1 ]
Yamaguchi, Hiroki [1 ]
Iwashita, Naoki [1 ,2 ]
Takagi, Yoshiichi [1 ,3 ]
Yoshinari, Tomoya [4 ]
Fukuyama, Tomoki [1 ,5 ]
机构
[1] Azabu Univ, Sch Vet Med, Lab Vet Pharmacol, 1-17-71 Fuchinobe,Chuo Ku, Sagamihara, Kanagawa 2525201, Japan
[2] Bioalch Co Ltd, 3-28 Honshuku Cho, Fuchu, Tokyo 1830032, Japan
[3] Japan SLC Inc, 85 Ohara Cho,Chuo Ku, Hamamatsu, Shizuoka 4311103, Japan
[4] Natl Inst Hlth Sci, Div Microbiol, 3-25-26 Tonomachi,Kawasaki Ku, Kawasaki, Kanagawa 2109501, Japan
[5] Azabu Univ, Ctr Human & Anim Symbiosis Sci, 1-17-71 Fuchinobe,Chuo Ku, Sagamihara, Kanagawa 2525201, Japan
关键词
fumonisin B1; fumonisin B2; IL-17; IL-22; psoriasis;
D O I
10.3390/ijms25147852
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
This study aimed to determine whether oral fumonisin exposure contributes to the development of psoriasis. Oral administration of fumonisin B1 (FB1, 0.1 mg/kg) or fumonisin B2 (FB2, 0.1 mg/kg) was conducted for 10 days, in addition to the induction of psoriatic symptoms through topical application of 5% imiquimod cream from day 6 to day 10 (5 days) in female BALB/c mice. The results demonstrated that oral administration of FB2 significantly exacerbated psoriatic symptoms, including skin thickness, itching behavior, transepidermal water loss, immune cell infiltration in the dermis, and proinflammatory cytokine production. However, no changes were observed following exposure to FB1. Our results confirm that oral exposure to FB2 adversely affects the pathogenesis of psoriasis by increasing skin thickness and impairing barrier function.
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页数:8
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