Role of TIM-1 in the development and treatment of tumours

被引:0
|
作者
Cao, Jinmeng [1 ,2 ,3 ]
Qing, Jilin [4 ]
Zhu, Liya [5 ]
Chen, Zhizhong [1 ,2 ]
机构
[1] Peoples Hosp Guangxi Zhuang Autonomous Reg, Joint Inspect Ctr Precis Med, Nanning, Guangxi, Peoples R China
[2] Guangxi Acad Med Sci, Nanning, Guangxi, Peoples R China
[3] Guilin Med Univ, Sch Clin Med, Guilin, Guangxi, Peoples R China
[4] Peoples Hosp Guangxi Zhuang Autonomous Reg, Ctr Reprod Med & Genet, Nanning, Guangxi, Peoples R China
[5] Guangxi Univ Chinese Med, Grad Sch, Nanning, Guangxi, Peoples R China
来源
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2024年 / 12卷
基金
中国国家自然科学基金;
关键词
TIM-1; tumour; target; the tumour microenvironment; therapy; T-CELL IMMUNOGLOBULIN; KIDNEY INJURY MOLECULE-1; COLORECTAL-CANCER; ACTIVATION; EXPRESSION; ANTIBODIES; TOLERANCE; RESPONSES; EFFECTOR; FAMILY;
D O I
10.3389/fcell.2024.1307806
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
T-cell immunoglobulin and mucin structural domain 1 (TIM-1, also known as hepatitis A virus cell receptor 1) is a co-stimulatory molecule that is expressed predominantly on the surface of T cells. TIM-1 promotes the activation and proliferation of T cells, cytokine secretion, and can also be overexpressed in various types of cancer. Upregulation of TIM-1 expression may be associated with the development and progression of cancer. After reviewing the literature, we propose that TIM-1 affects tumour development mainly through two pathways. In the Direct pathway: overexpression in tumours activates tumour-related signaling pathways, mediates the proliferation, apoptosis, invasion and metastasis, and directly affects tumour development directly. In the indirect pathway: In addition to changing the tumour microenvironment and influencing the growth of tumours, TIM-1 binds to ligands to encourage the activation, proliferation, and generation of cytokines by immune cells. This review examines how TIM-1 stimulates the development of tumours in direct and indirect ways, and how TIM-1 is exploited as a target for cancer therapy.
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收藏
页数:10
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