p53: A tale of complexity and context

被引：2

作者：

Oren, Moshe ^{[1
]}

Prives, Carol ^{[2
]}

机构：

[1] Weizmann Inst Sci, Dept Mol Cell Biol, Rehovot, Israel

[2] Columbia Univ, Dept Biol Sci, New York, NY 10027 USA

来源：

CELL | 2024年 / 187卷 / 07期

基金：

以色列科学基金会;

关键词：

TUMOR SUPPRESSION; CANCER; TP53;

D O I：

10.1016/j.cell.2024.02.043

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The story of p53 is illuminating. Despite widespread attention, the tumor-suppressive functions of wild -type p53 or the oncogenic activities of its cancer -associated mutants are still not fully understood, and our discoveries have not yet led to major therapeutic breakthroughs. There is still much to learn about this fascinating protein.

引用

页码：1569 / 1573

页数：5

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