The art of healing hearts: Mastering advanced RNA therapeutic techniques to shape the evolution of cardiovascular medicine in biomedical science

被引：1

作者：

Hou, Guoliang ^{[1
]}

Alissa, Mohammed ^{[2
]}

Alsuwat, Meshari A. ^{[3
]}

Alarjany, Hanan Mohammed Ali ^{[4
]}

Alzahrani, Khalid J. ^{[3
]}

Althobaiti, Fahad M. ^{[5
]}

Mujalli, Hussain Mohammed ^{[6
]}

Alotaiby, Monearah M. ^{[7
]}

Al-Doaiss, Amin A. ^{[8
]}

Anthony, Stefan ^{[9
]}

机构：

[1] Tengzhou Cent Peoples Hosp, Dept Cardiol, Shandong 277599, Peoples R China

[2] Prince Sattam bin Abdulaziz Univ, Coll Appl Med Sci, Dept Med Lab, Al Kharj 11942, Saudi Arabia

[3] Taif Univ, Coll Appl Med Sci, Dept Clin Lab Sci, Taif 21974, Saudi Arabia

[4] Minist Hlth, Nursing & Clin Care Serv, Najran 66241, Saudi Arabia

[5] Taif Univ, Nursing Coll, Dept Nursing Leadership & Educ, Taif 21974, Saudi Arabia

[6] Abu Arish Gen Hosp, Minist Hlth, Jazan 45142, Saudi Arabia

[7] Minist Hlth, Dept Lab, King Faisal Med Complex, Taif 26514, Saudi Arabia

[8] King Khalid Univ, Coll Sci, Biol Dept, POB 9004, Abha 61413, Saudi Arabia

[9] Dalian Med Univ Liaoning Provence China, Dept Physiol, Liaoning Prov Key Lab Cerebral Dis, Dalian, Peoples R China

来源：

CURRENT PROBLEMS IN CARDIOLOGY | 2024年 / 49卷 / 08期

关键词：

RNA; Cardiovascular diseases; Personalized medicine; LONG NONCODING RNAS; CIRCULAR RNA; MYOCARDIAL-INFARCTION; ANTISENSE OLIGONUCLEOTIDES; GENE-TRANSFER; EXPRESSION; MOUSE; BIOMARKERS; DIAGNOSIS; MODEL;

D O I：

10.1016/j.cpcardiol.2024.102627

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cardiovascular diseases (CVDs) are the leading cause of death worldwide and are associated with increasing financial health burden that requires research into novel therapeutic approaches. Since the early 2000s, the availability of next-generation sequencing techniques such as microRNAs, circular RNAs, and long non-coding RNAs have been proven as potential therapeutic targets for treating various CVDs. Therapeutics based on RNAs have become a viable option for addressing the intricate molecular pathways that underlie the pathophysiology of CVDs. We provide an indepth analysis of the state of RNA therapies in the context of CVDs, emphasizing various approaches that target the various stages of the basic dogma of molecular biology to effect temporary or long-term changes. In this review, we summarize recent methodologies used to screen for novel coding and non-coding RNA candidates with diagnostic and treatment possibilities in cardiovascular diseases. These methods include single-cell sequencing techniques, functional RNA screening, and next-generation sequencing.Lastly, we highlighted the potential of using oligonucleotide-based chemical products such as modified RNA and RNA mimics/inhibitors for the treatment of CVDs. Moreover, there will be an increasing number of potential RNA diagnostic and therapeutic for CVDs that will progress to expand for years to come.

引用

页数：13