Advantage in Aging Cognition Associated with the CREBRF variant rs373863828 Among Samoans

被引：0

作者：

Levy, Becca R. ^{[1
,2
,11
]}

Viali, Satupa'itea ^{[3
]}

Naseri, Take ^{[4
]}

Reupena, Muagututia Sefuiva ^{[5
]}

Faasalele-Savusa, Kima ^{[6
,7
]}

Filipo, Vaimoana ^{[6
,7
]}

Kershaw, Erin E. ^{[8
]}

Huang, Yuan ^{[9
]}

Slade, Martin D. ^{[10
]}

机构：

[1] Yale Sch Publ Hlth, Dept Social Behav Sci, New Haven, CT USA

[2] Yale Univ, Dept Psychol, New Haven, CT USA

[3] Samoan Natl Univ, Apia, Samoa

[4] Govt Samoa, Minist Hlth, Apia, Samoa

[5] Govt Samoa, Bur Stat, Apia, Samoa

[6] Samoan Obes Lifestyle & Genet Adaptat Study Grp, Apia, Samoa

[7] Yale Sch Publ Hlth, New Haven, CT USA

[8] Univ Pittsburgh, Div Endocrinol & Metab, Pittsburgh, PA USA

[9] Yale Sch Publ Hlth, Dept Biostat, New Haven, CT USA

[10] Yale Sch Med, Dept Internal Med, New Haven, CT USA

[11] Yale Sch Publ Hlth, Dept Social & Behav Sci, 60 Coll St,POB 208034, New Haven, CT 06520 USA

来源：

GEROPSYCH-THE JOURNAL OF GERONTOPSYCHOLOGY AND GERIATRIC PSYCHIATRY | 2024年 / 37卷 / 04期

关键词：

cognition; aging; Samoa; genetics; CREBRF; ALZHEIMER-DISEASE; BODY-SIZE; RISK; DECLINE;

D O I：

10.1024/1662-9647/a000338

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

We examined whether the A allele of CREBRF rs373863828, which is common in Samoans but rare in non-Pacific Islanders, predicts better cognition. Samoan interviewers interviewed participants who were 60 years and older, lived in the Independent State of Samoa, and had four Samoan grandparents. The AA genotype significantly predicted older Samoans' better subjective and objective cognition; it also contributed 5.9 times more than APOE to subjective cognition and 12.3 times more than APOE to objective cognition, in effect-size analyses. Since CREBRF operates in the universal CREB system, the findings could inform general aging-cognition resilience.

引用

页码：193 / 198

页数：6

共 33 条

[1] The missense variant, rs373863828, in CREBRF plays a role in longitudinal changes in body mass index in Samoans
Fu, Haoyi
Hawley, Nicola L.
Carlson, Jenna C.
Russell, Emily M.
Pomer, Alysa
Cheng, Hong
Naseri, Take
Reupena, Muagututi'a Sefuiva
Deka, Ranjan
Choy, Courtney C.
McGarvey, Stephen T.
Minster, Ryan L.
Weeks, Daniel E.
OBESITY RESEARCH & CLINICAL PRACTICE, 2022, 16 (03) : 220 - 227
[2] The impact of CREBRF rs373863828 Pacific-variant on infant body composition
Amitrano, Francesca
Krishnan, Mohanraj
Murphy, Rinki
Okesene-Gafa, Karaponi A. M.
Ji, Maria
Thompson, John M. D.
Taylor, Rennae S.
Merriman, Tony R.
Rush, Elaine
McCowan, Megan
McCowan, Lesley M. E.
McKinlay, Christopher J. D.
SCIENTIFIC REPORTS, 2024, 14 (01)
[3] A missense variant in CREBRF, rs373863828, is associated with fat-free mass, not fat mass in Samoan infants
Arslanian, K. J.
Fidow, U. T.
Atanoa, T.
Naseri, T.
Duckham, R. L.
McGarvey, S. T.
Oyama, S.
Choy, C. C.
Kershaw, E. E.
Hawley, N. L.
AMERICAN JOURNAL OF HUMAN BIOLOGY, 2020, 32
[4] A missense variant in CREBRF, rs373863828, is associated with fat-free mass, not fat mass in Samoan infants
K. J. Arslanian
U. T. Fidow
T. Atanoa
F. Unasa-Apelu
T. Naseri
A. I. Wetzel
A. Pomer
R. L. Duckham
S. T. McGarvey
J. A. Strayer
E. E. Kershaw
D. E. Weeks
N. L. Hawley
International Journal of Obesity, 2021, 45 : 45 - 55
[5] The minor allele of the CREBRF rs373863828 p.R457Q coding variant is associated with reduced levels of myostatin in males: Implications for body composition
Lee, Kate
Vakili, Sanaz
Burden, Hannah J.
Adams, Shannon
Smith, Greg C.
Kulatea, Braydon
Wright-McNaughton, Morag
Sword, Danielle
Watene-O'Sullivan, Conor
Atiola, Robert D.
Paul, Ryan G.
Plank, Lindsay D.
Kallingappa, Prasanna
King, Frances
Wilcox, Phillip
Merriman, Tony R.
Krebs, Jeremy D.
Hall, Rosemary M.
Murphy, Rinki
Merry, Troy L.
Shepherd, Peter R.
MOLECULAR METABOLISM, 2022, 59
[6] A missense variant in CREBRF is associated with taller stature in Samoans
Carlson, Jenna C.
Rosenthal, Samantha L.
Russell, Emily M.
Hawley, Nicola L.
Sun, Guangyun
Cheng, Hong
Naseri, Take
Reupena, Muagututi'a S.
Tuitele, John
Deka, Ranjan
McGarvey, Stephen T.
Weeks, Daniel E.
Minster, Ryan L.
AMERICAN JOURNAL OF HUMAN BIOLOGY, 2020, 32 (06)
[7] Association study of CREBRF missense variant (rs373863828:G > A; p.Arg457Gln) with levels of serum lipid profile in the Pacific populations
Ohashi, Jun
Naka, Izumi
Furusawa, Takuro
Kimura, Ryosuke
Natsuhara, Kazumi
Yamauchi, Taro
Nakazawa, Minato
Ishida, Takafumi
Inaoka, Tsukasa
Matsumura, Yasuhiro
Ohtsuka, Ryutaro
ANNALS OF HUMAN BIOLOGY, 2018, 45 (03) : 215 - 219
[8] The protective effect of rs373863828 on type 2 diabetes does not operate through a body composition pathway in adult Samoans
Hawley, Nicola L.
Duckham, Rachel L.
Carlson, Jenna C.
Naseri, Take
Reupena, Muagututia Sefuiva
Lameko, Viali
Pomer, Alysa
Wetzel, Abigail
Selu, Melania
Lupematisila, Vaimoana
Unasa, Folla
Vesi, Lupesina
Fatu, Tracy
Unasa, Seipepa
Faasalele-Savusa, Kima
Rivara, Anna C.
Russell, Emily
Delany, James P.
Viali, Satupaitea
Kershaw, Erin E.
Minster, Ryan L.
Weeks, Daniel E.
McGarvey, Stephen T.
OBESITY, 2022, 30 (12) : 2468 - 2476
[9] A missense variant inCREBRF, rs373863828, is associated with fat-free mass, not fat mass in Samoan infants
Arslanian, K. J.
Fidow, U. T.
Atanoa, T.
Unasa-Apelu, F.
Naseri, T.
Wetzel, A. I.
Pomer, A.
Duckham, R. L.
McGarvey, S. T.
Strayer, J. A.
Kershaw, E. E.
Weeks, D. E.
Hawley, N. L.
INTERNATIONAL JOURNAL OF OBESITY, 2021, 45 (01) : 45 - 55
[10] The Pacific-specific CREBRF rs373863828 allele protects against gestational diabetes mellitus in Maori and Pacific women with obesity
Krishnan, Mohanraj
Murphy, Rinki
Okesene-Gafa, Karaponi A. M.
Ji, Maria
Thompson, John M. D.
Taylor, Rennae S.
Merriman, Tony R.
McCowan, Lesley M. E.
McKinlay, Christopher J. D.
DIABETOLOGIA, 2020, 63 (10) : 2169 - 2176

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