Treatable Traits in Asthma: The Importance of Extrapulmonary Traits-GERD, CRSwNP, Atopic Dermatitis, and Depression/Anxiety

被引：12
|
作者：
Mcdonald, Vanessa M. [1 ,2 ,5 ]
Hamada, Yuto [1 ,3 ]
Agusti, Alvar [4 ]
Gibson, Peter G. [1 ,2 ]
机构：
[1] Univ Newcastle, Coll Hlth Med & Well being, Ctr Excellence Treatable Traits, New Lambton Hts, NSW, Australia
[2] John Hunter Hosp, Dept Resp & Sleep Med, New Lambton Hts, NSW, Australia
[3] Natl Hosp Org Sagamihara Natl Hosp, Clin Res Ctr Allergy & Rheumatol, Kanagawa, Japan
[4] Univ Barcelona, Hosp Clin, Resp Inst, IDIBAPS,CIBERES, Barcelona, Spain
[5] Univ Newcastle, Hunter Med Res Inst HMRI, Coll Hlth Med & Wellbeing, Level 2W,Lot 1, New Lambton Hts, NSW 2305, Australia
来源：
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE | 2024年 / 12卷 / 04期
关键词：
Asthma; Treatable traits; Extrapulmonary; Personalized; GASTROESOPHAGEAL-REFLUX DISEASE; QUALITY-OF-LIFE; EXACERBATED RESPIRATORY-DISEASE; CHRONIC RHINOSINUSITIS; DIAGNOSTIC-CRITERIA; RISK-FACTORS; ANTIREFLUX SURGERY; HOSPITAL ANXIETY; ESOPHAGEAL ACID; ALLERGIC-ASTHMA;
D O I：
10.1016/j.jaip.2024.01.020
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
lifestyle/risk factor traits, and applying targeted treatments to effectively manage these traits, enables a holistic and personalized approach to care. Asthma is a heterogeneous andTreatable traits is a personalized medicine approach to the management of airway disease. Assessing traits within the 3 domains of pulmonary, extrapulmonary, and behavioral/complex airway disease that is frequently complicated by several extrapulmonary traits that impact asthma outcomes and predict future outcomes. We propose that the identi fi- cation of extrapulmonary and behavioral risk factor traits and the implementation of targeted therapy will lead to improved management of people with asthma. Furthermore, many extrapulmonary traits present as "connected comorbidities "; that is, they coexist with asthma, have an impact on asthma, and effective treatment improves both asthma and the comorbidity or the comorbidities may share a similar mechanism. In this review, we explore this concept and look at atopic dermatitis, chronic rhinosinusitis with nasal polyps, gastroesophageal re flux disease, anxiety, and depression as treatable traits of asthma and how these can be managed using this approach. (c) 2024 American Academy of Allergy, Asthma & Immunology (J Allergy Clin Immunol Pract 2024;12:824-37)
引用
收藏
页码：824 / 837
页数：14
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