Muscle Network Connectivity Study in Diabetic Peripheral Neuropathy Patients

被引:0
|
作者
Junquera-Godoy, Isabel [1 ]
Martinez-De-Juan, Jose Luis [1 ]
Gonzalez-Lorente, Gemma [1 ]
Carot-Sierra, Jose Miguel [2 ]
Gomis-Tena, Julio [1 ]
Saiz, Javier [1 ]
Garcia-Blasco, Silvia [3 ]
Pertusa-Mazon, Isabel [3 ]
Soler-Climent, Esther [4 ]
Prats-Boluda, Gema [1 ]
机构
[1] Univ Politecn Valencia UPV, Ctr Invest Innovac Bioingn Ci2B, Valencia 46022, Spain
[2] Univ Politecn Valencia UPV, Dept Estadist Invest Operat Aplicadas & Cal, Valencia 46022, Spain
[3] Elche Hosp Gen FISABIO, Serv Rehabil, Dept Salud, Elche 03203, Spain
[4] Elche Hosp Gen FISABIO, Area Invest Enfermeria Fisioterapia, Dept Salud, Elche 03203, Spain
关键词
electromyography; diabetic peripheral neuropathy; biomarker; muscle interaction; transfer entropy; ACTIVATION; COMPLEXITY; MELLITUS; PATTERNS;
D O I
10.3390/s24154954
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Diabetic peripheral neuropathy (DPN) is a prevalent complication of chronic diabetes mellitus and has a significant impact on quality of life. DPN typically manifests itself as a symmetrical, length-dependent sensorimotor polyneuropathy with severe effects on gait. Surface electromyography (sEMG) is a valuable low-cost tool for assessing muscle activation patterns and precise identification of abnormalities. For the present study, we used information theory methods, such as cross-correlation (CC), normalized mutual information (NMI), conditional granger causality (CG-Causality), and transfer entropy (TE), to evaluate muscle network connectivity in three population groups: 33 controls (healthy volunteers, CT), 10 diabetic patients with a low risk of DPN (LW), and 17 moderate/high risk patients (MH). The results obtained indicated significant alterations in the intermuscular coupling mechanisms due to diabetes and DPN, with the TE group showing the best performance in detecting differences. The data revealed a significant increase in information transfer and muscle connectivity in the LW group over the CT group, while the MH group obtained significantly lower values for these metrics than the other two groups. These findings highlight the sEMG coupling metrics' potential to reveal neuromuscular mechanisms that could aid the development of targeted rehabilitation strategies and help monitor DPN patients.
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页数:17
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