Shaping the future of gastrointestinal cancers through metabolic interactions with host gut microbiota

被引：1
|
作者：
Xie, Wen [1 ,2 ]
Sharma, Aditi [3 ]
Kaushik, Hitesh [3 ]
Sharma, Lalit [3 ]
Nistha [3 ]
Anwer, Md Khalid [4 ]
Sachdeva, Monika [5 ]
Elossaily, Gehan M. [6 ]
Zhang, Yingbo [11 ]
Pillappan, Ramkumar [7 ]
Kaur, Maninderjit [8 ]
Behl, Tapan [9 ]
Shen, Bairong [1 ,2 ]
Singla, Rajeev K. [1 ,2 ,10 ]
机构：
[1] Sichuan Univ, West China Hosp, Dept Pharm, Chengdu 610041, Sichuan, Peoples R China
[2] Sichuan Univ, West China Hosp, Inst Syst Genet, Ctr High Altitude Med,Frontiers Sci Ctr Dis relate, Chengdu 610041, Sichuan, Peoples R China
[3] Shoolini Univ, Sch Pharmaceut Sci, Solan 173229, HP, India
[4] Prince Sattam Bin Abdulaziz Univ, Coll Pharm, Dept Pharmaceut, Alkharj, Saudi Arabia
[5] Fatima Coll Hlth Sci, Al Ain, U Arab Emirates
[6] AlMaarefa Univ, Coll Med, Dept Basic Med Sci, POB 71666, Riyadh 11597, Saudi Arabia
[7] Nitte Deemed Univ, NGSM Inst Pharmaceut Sci, Mangalore, Karnataka, India
[8] Lovely Profess Univ, Dept Pharmaceut Sci, Phagwara, India
[9] Amity Univ, Amity Sch Pharmaceut Sci, Sahibzada Ajit Singh Naga, Punjab, India
[10] Lovely Profess Univ, Sch Pharmaceut Sci, Phagwara 1444411, Punjab, India
[11] Sichuan Univ, West China Tianfu Hosp, West China Hosp, Inst Syst Genet,,Frontiers Sci Ctr Dis related Mol, Chengdu 610218, Sichuan, Peoples R China
来源：
HELIYON | 2024年 / 10卷 / 15期
基金：
中国国家自然科学基金;
关键词：
Gastrointestinal cancers; Microbiome research; Metabolic interplay; Precision diagnosis; Therapeutic approaches; Microbiome; INTERNATIONAL SCIENTIFIC ASSOCIATION; TRYPTOPHAN-METABOLISM; PERSONALIZED MEDICINE; CONSENSUS STATEMENT; DRUG INTERACTIONS; BACTERIA; BUTYRATE; MECHANISMS; PROBIOTICS; DIVERSITY;
D O I：
10.1016/j.heliyon.2024.e35336
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Gastrointestinal (GI) cancers represent a significant global health challenge, driving relentless efforts to identify innovative diagnostic and therapeutic approaches. Recent strides in micro- biome research have unveiled a previously underestimated dimension of cancer progression that revolves around the intricate metabolic interplay between GI cancers and the host's gut micro- biota. This review aims to provide a comprehensive overview of these emerging metabolic interactions and their potential to catalyze a paradigm shift in precision diagnosis and therapeutic breakthroughs in GI cancers. The article underscores the groundbreaking impact of microbiome research on oncology by delving into the symbiotic connection between host metabolism and the gut microbiota. It offers valuable insights into tailoring treatment strategies to individual patients, thus moving beyond the traditional one-size-fits-all approach. This review also sheds light on novel diagnostic methodologies that could transform the early detection of GI cancers, potentially leading to more favorable patient outcomes. In conclusion, exploring the metabolic interactions between host gut microbiota and GI cancers showcases a promising frontier in the ongoing battle against these formidable diseases. By comprehending and harnessing the microbiome's influence, the future of precision diagnosis and therapeutic innovation for GI cancers appears more optimistic, opening doors to tailored treatments and enhanced diagnostic precision.
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页数：16
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