Current Status of Poultry Recombinant Virus Vector Vaccine Development

被引：5
|
作者：
Wang, Haoran [1 ,2 ]
Tian, Jiaxin [1 ,2 ]
Zhao, Jing [1 ,2 ]
Zhao, Ye [1 ,2 ]
Yang, Huiming [1 ,2 ]
Zhang, Guozhong [1 ,2 ]
机构：
[1] China Agr Univ, Coll Vet Med, Natl Key Lab Vet Publ Hlth Secur, Beijing 100193, Peoples R China
[2] China Agr Univ, Coll Vet Med, Key Lab Anim Epidemiol, Minist Agr, Beijing 100193, Peoples R China
来源：
VACCINES | 2024年 / 12卷 / 06期
关键词：
poultry; vaccines; fowl poxvirus; fowl adenovirus; Newcastle disease virus; Marek's disease virus; herpesvirus of turkey; NEWCASTLE-DISEASE VIRUS; INFECTIOUS BURSAL DISEASE; INFLUENZA HEMAGGLUTININ GENE; FOWL POXVIRUS VACCINE; ONE-STEP GENERATION; MAREKS-DISEASE; BRONCHITIS VIRUS; PROTECTIVE IMMUNITY; EXPRESSING VP2; FOREIGN GENE;
D O I：
10.3390/vaccines12060630
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Inactivated and live attenuated vaccines are the mainstays of preventing viral poultry diseases. However, the development of recombinant DNA technology in recent years has enabled the generation of recombinant virus vector vaccines, which have the advantages of preventing multiple diseases simultaneously and simplifying the vaccination schedule. More importantly, some can induce a protective immune response in the presence of maternal antibodies and offer long-term immune protection. These advantages compensate for the shortcomings of traditional vaccines. This review describes the construction and characterization of primarily poultry vaccine vectors, including fowl poxvirus (FPV), fowl adenovirus (FAdV), Newcastle disease virus (NDV), Marek's disease virus (MDV), and herpesvirus of turkey (HVT). In addition, the pathogens targeted and the immunoprotective effect of different poultry recombinant virus vector vaccines are also presented. Finally, this review discusses the challenges in developing vector vaccines and proposes strategies for improving immune efficacy.
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页数：27
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