Human-computer interaction is a globally significant multidisciplinary field to enhance the usability of electronic devices for work, entertainment, and educational activities about human beings. Within the Ibero-American region, a community of researchers specializing in Human-computer interaction and related interdisciplinary domains has been established. Hence, it is crucial to understand this field's current state and evolution to identify critical contributors, institutions, information sources, and knowledge networks. This knowledge enables the contextualization of research, project planning, resource management, and improved dissemination within the domain. This study employed the Science Mapping Workflow methodology and specialized tools like Bibliometrix to conduct a bibliometric analysis of Human-computer interaction in Ibero-America. The findings reveal that the domain is well-established at the Ibero-American level and exhibits a growth rate of 14.65% in publications, indicating consistent progress. Moreover, Spain and Brazil have emerged as leading contributors in this field. Regarding the knowledge structure, it is evident that numerous technological advancements are focused on enhancing the capabilities of individuals with disabilities or limitations. Furthermore, video games, computer-mediated communication, natural interfaces, and artificial intelligence are identified as prominent trends within Human-computer interaction.