Kidney Transplantation Outcomes From Uncontrolled Donation After Circulatory Death: A Systematic Review and Meta-analysis

被引:0
|
作者
Vijayan, Keshini [1 ]
Schroder, Hugh J. [1 ]
Hameed, Ahmer [1 ,2 ]
Hitos, Kerry [1 ,2 ]
Lo, Warren [3 ]
Laurence, Jerome M. [4 ]
Yoon, Peter D. [2 ]
Nahm, Christopher [1 ,2 ]
Lim, Wai H. [5 ,6 ]
Lee, Taina [2 ]
Yuen, Lawrence [2 ]
Wong, Germaine [1 ,7 ]
Pleass, Henry [1 ,2 ]
机构
[1] Univ Sydney, Fac Med & Hlth Sci, Westmead Clin Sch, Sydney, NSW, Australia
[2] Westmead Hosp, Dept Surg, Sydney, NSW, Australia
[3] Kuala Lumpur Gen Hosp, Inst Urol & Nephrol, Kuala Lumpur, Malaysia
[4] Univ Sydney, Fac Med & Hlth, Cent Clin Sch, Sydney, NSW, Australia
[5] Sir Charles Gairdner Hosp, Dept Renal Med, Perth, WA, Australia
[6] Univ Western Australia, Med Sch, Perth, WA, Australia
[7] Westmead Hosp, Dept Renal Med, Sydney, NSW, Australia
关键词
HEART-BEATING DONOR; CARDIAC DEATH; IN-SITU; PERFUSION; ORGANS;
D O I
10.1097/TP.0000000000004937
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Background. Uncontrolled donation after circulatory death (uDCD) is a potential additional source of donor kidneys. This study reviewed uDCD kidney transplant outcomes to determine if these are comparable to controlled donation after circulatory death (cDCD).Methods. MEDLINE, Cochrane, and Embase databases were searched. Data on demographic information and transplant outcomes were extracted from included studies. Meta-analyses were performed, and risk ratios (RR) were estimated to compare transplant outcomes from uDCD to cDCD.Results. Nine cohort studies were included, from 2178 uDCD kidney transplants. There was a moderate degree of bias, as 4 studies did not account for potential confounding factors. The median incidence of primary nonfunction in uDCD was 12.3% versus 5.7% for cDCD (RR, 1.85; 95% confidence intervals, 1.06-3.23; P = 0.03, I2 = 75). The median rate of delayed graft function was 65.1% for uDCD and 52.0% for cDCD. The median 1-y graft survival for uDCD was 82.7% compared with 87.5% for cDCD (RR, 1.43; 95% confidence intervals, 1.02-2.01; P = 0.04; I2 = 71%). The median 5-y graft survival for uDCD and cDCD was 70% each. Notably, the use of normothermic regional perfusion improved primary nonfunction rates in uDCD grafts.Conclusions. Although uDCD outcomes may be inferior in the short-term, the long-term outcomes are comparable to cDCD.
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页码:1422 / 1429
页数:8
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