Testosterone therapy over 60 months improves aging male symptoms scores in all men with adult-onset testosterone deficiency

ObjectiveWe evaluated change (Delta) in AMSS in men with adult-onset testosterone deficiency (TD) on/not on testosterone undecanoate (TU) by analysing a registry of men with adult-onset TD.MethodsAnalyses were performed using non-parametric statistics to determine Delta AMSS at 6-12 monthly intervals in men on/not on TU and movement in AMSS. Factors predicting Delta AMSS were established via linear/multiple regression.ResultsTU was significantly associated with lower AMSS values compared with that at baseline/prior assessment during the initial 42 months treatment; 259 of the 260 men showed improvement. In the 361 men not on TU, AMSS values increased during 60 months of follow-up compared with that at baseline/prior assessment; improvement after 60 months was evident in 1 man, whilst AMSS remained the same or worsened in 213 and 147 men, respectively. In men on TU, baseline AMSS was inversely associated with Delta AMSS (R2 = 0.97), with no other factors reaching significance. Baseline AMSS, age, serum total testosterone (TT), waist circumference (WC), and diastolic blood pressure (BP) were associated with Delta AMSS in men not on TU.DiscussionWe show that TU was associated with lower AMSS in men with adult-onset TD whilst non-treatment led to increased values. Baseline AMSS values inversely predicted Delta AMSS in both groups.