MONOCYTE-LYMPHOCYTE, NEUTROPHIL-LYMPHOCYTE, AND PLATELET-LYMPHOCYTE RATIOS AS INFLAMMATORY BIOMARKERS OF CLINICAL DENGUE SEVERITY

被引：0
|
作者：
Boer, Luiza Monteiro [1 ]
Junqueira, Isabela Cinquini [2 ]
Do Nascimento, Thais Cardoso [1 ]
Guilarde, Adriana Oliveira [2 ]
Feres, Valeria Christina De Rezende [3 ]
De Alcantara, Keila Correia
机构：
[1] Univ Fed Goias, Sch Pharm, Postgrad Program Hlth Care & Assessment, Goiania, GO, Brazil
[2] Univ Fed Goias, Trop Pathol & Publ Hlth Inst, Goiania, GO, Brazil
[3] Univ Fed Goias, Sch Pharm, Goiania, GO, Brazil
来源：
BIOSCIENCE JOURNAL | 2024年 / 40卷
关键词：
Blood cell count; Dengue hemorrhagic fever; Dengue virus; Leukocyte count; Prognostic; MORTALITY;
D O I：
10.14393/BJ-v40n0a2024-67413
中图分类号：
S [农业科学];
学科分类号：
09 ;
摘要：
The literature describes monocyte-lymphocyte (MLR), neutrophil-lymphocyte (NLR), and plateletlymphocyte (PLR) ratios as prognostic biomarkers. However, in the case of dengue infection, patient clinical management and nonspecific laboratory tests determine the prognosis. Therefore, this study analyzed MLR, NLR, and PLR as prognostic biomarkers of dengue infection. Our study was based on a clinical cohort of dengue patients in Brazil between 2012 and 2013. From 193 patients, 164 (85.0%) were classified as dengue fever (DF), 19 (9.8%) as dengue hemorrhagic fever (DHF), and 10 (5.2%) as intermediate DF/DHF. DHF cases were significantly associated with MLR > 0.13 (OR: 5.72, 95% CI: 1.2825.60, p < 0.05) and PLR <= 80.68 (OR: 4.26; 95% CI 1.60-11.33; p < 0.05). Our results suggest that MLR increase, and PLR decrease indicate a higher likelihood of worsening the clinical status.
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页数：8
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