Cardiac allograft vasculopathy (CAV) is one of the leading causes of graft failure and death after heart transplantation. Alloimmune-dependent and -independent factors trigger the pathogenesis of CAV through activation of the recipients' (and to a lesser extent donor-derived) immune system. Early diagnosis of CAV is complicated by the lack of clinical symptoms for ischemia in the denervated heart, by the impact of early functional coronary alterations, by the insensitivity of coronary angiography, and by the involvement of small intramyocardial vessels. CAV in general is a panarterial disease confined to the allograft and characterized by diffuse concentric longitudinal intimal hyperplasia in the epicardial coronary arteries and concentric medial disease in the microvasculature. Plaque composition in CAV may include early fibrous and fibrofatty tissue and late atheromatous calcification. In contrast, native coronary atherosclerosis usually develops over decades, is focal, noncircumferential, and typically diminishes proximal parts of the epicardial vessels. The rapid and early development of CAV has an adverse prognostic impact, and current prevention and treatment strategies are of limited efficacy compared with established strategies in native atherosclerosis. Following acute coronary syndromes, patients after heart transplantation were more likely to have accompanying cardiogenic shock and higher mortality compared with acute coronary syndromes patients with native hearts.
机构:
Zhejiang Univ, Sch Med, Affiliated Hosp 2, Cardiovasc Res Fdn, New York, NY USAZhejiang Univ, Sch Med, Affiliated Hosp 2, Cardiovasc Res Fdn, New York, NY USA
Dong, Liang
论文数: 引用数:
h-index:
机构:
Nazif, Tamim
Mancini, Donna
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, Med Ctr, New York Presbyterian Hosp, New York, NY USAZhejiang Univ, Sch Med, Affiliated Hosp 2, Cardiovasc Res Fdn, New York, NY USA
Mancini, Donna
Rabbani, LeRoy
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, Med Ctr, New York, NY USAZhejiang Univ, Sch Med, Affiliated Hosp 2, Cardiovasc Res Fdn, New York, NY USA
Rabbani, LeRoy
Apfelbaum, Mark A.
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, Med Ctr, New York Presbyterian Hosp, New York, NY USAZhejiang Univ, Sch Med, Affiliated Hosp 2, Cardiovasc Res Fdn, New York, NY USA
Apfelbaum, Mark A.
Pollack, Ari T.
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, Med Ctr, New York Presbyterian Hosp, New York, NY USAZhejiang Univ, Sch Med, Affiliated Hosp 2, Cardiovasc Res Fdn, New York, NY USA
Pollack, Ari T.
Dalton, Kate
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, Med Ctr, New York Presbyterian Hosp, New York, NY USAZhejiang Univ, Sch Med, Affiliated Hosp 2, Cardiovasc Res Fdn, New York, NY USA
Dalton, Kate
Mintz, Gary S.
论文数: 0引用数: 0
h-index: 0
机构:
Cardiovasc Res Fdn, Washington, DC USAZhejiang Univ, Sch Med, Affiliated Hosp 2, Cardiovasc Res Fdn, New York, NY USA
Mintz, Gary S.
Maehara, Akiko
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, Med Ctr, New York, NY USA
Cardiovasc Res Fdn, New York, NY USAZhejiang Univ, Sch Med, Affiliated Hosp 2, Cardiovasc Res Fdn, New York, NY USA
Maehara, Akiko
Weisz, Giora
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, New York, NY USAZhejiang Univ, Sch Med, Affiliated Hosp 2, Cardiovasc Res Fdn, New York, NY USA
机构:
Montana State Univ, Land Resources & Environm Sci Dept, Bozeman, MT 59717 USAMontana State Univ, Land Resources & Environm Sci Dept, Bozeman, MT 59717 USA
Taylor, Kimberley T.
Maxwell, Bruce D.
论文数: 0引用数: 0
h-index: 0
机构:
Montana State Univ, Land Resources & Environm Sci Dept, Bozeman, MT 59717 USAMontana State Univ, Land Resources & Environm Sci Dept, Bozeman, MT 59717 USA
Maxwell, Bruce D.
Pauchard, Anibal
论文数: 0引用数: 0
h-index: 0
机构:
Univ Concepcion, Fac Ciencias Forestales, Casilla 160-C, Concepcion, Chile
IEB, Santiago, ChileMontana State Univ, Land Resources & Environm Sci Dept, Bozeman, MT 59717 USA
Pauchard, Anibal
Nunez, Martin A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Nacl Comahue, Grp Ecol Invas, INIBIOMA, CONICET, Quintral 1250, RA-8400 San Carlos De Bariloche, Rio Negro, ArgentinaMontana State Univ, Land Resources & Environm Sci Dept, Bozeman, MT 59717 USA
Nunez, Martin A.
Rew, Lisa J.
论文数: 0引用数: 0
h-index: 0
机构:
Montana State Univ, Land Resources & Environm Sci Dept, Bozeman, MT 59717 USAMontana State Univ, Land Resources & Environm Sci Dept, Bozeman, MT 59717 USA