BrOnsted Acid Catalyzed Intramolecular Allylic Substitution Reaction of Allylic Alcohols: A Facile Synthesis of 2-Vinylchromans

被引：0
|
作者：
Li, Yun-Fan [1 ]
Xi, Yu-Ting [1 ]
Hu, Kai-Ji [1 ]
Tan, Qitao [1 ]
Ding, Chang-Hua [1 ]
Xu, Bin [1 ,2 ]
机构：
[1] Shanghai Univ, Dept Chem, Shanghai Engn Res Ctr Organ Repair, Innovat Drug Res Ctr, Shanghai 200444, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
来源：
SYNLETT | 2024年
关键词：
BrOnsted acid; allylic substitution reaction; allylic alcohol; chroman; metal-free reactions; ASYMMETRIC-SYNTHESIS; ALKYLATION; CHROMANS; TERTIARY; PHENOLS; CYCLOADDITION; HETEROCYCLES; ALLYLATION; ANNULATION; FLAVONOIDS;
D O I：
10.1055/a-2301-9223
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Bronsted acid-catalyzed intramolecular allylic substitution reaction of secondary and tertiary allylic alcohols has been developed. A variety of 2-vinylchromans were efficiently prepared in moderate to excellent yields. The given method features wide substrate scope, operational simplicity, metal-free, and mild reaction conditions. The practicability of the method was demonstrated by the gram-scale reaction and further derivations of the product. Catalytic asymmetric reaction was preliminarily studied. © 2024 Georg Thieme Verlag. All rights reserved.
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页数：5
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