Exosomes isolated from citrus lemon: a promising candidate for the treatment of Alzheimer's disease

被引：3
|
作者：
Dolma, Lobzang [1 ]
Damodaran, Aswin [1 ]
Panonnummal, Rajitha [1 ]
Nair, Sreeja C. [1 ]
机构：
[1] Amrita Vishwa Vidyapeetham, Amrita Sch Pharm, Kochi 682041, Kerala, India
来源：
THERAPEUTIC DELIVERY | 2024年 / 15卷 / 07期
关键词：
Alzheimer's disease; antioxidant; beta-amyloid; citrus lemon; exosomes like nanovesicles; SHSY-5Y cells; VITAMIN-C; OXIDATIVE STRESS; JUICES; PLANT; CELL;
D O I：
10.1080/20415990.2024.2354119
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Aim: To investigate the efficacy of exosome-like nanovesicles from citrus lemon (EXO-CLs) in combating oxidative stress associated with Alzheimer's disease. Materials & methods: EXO-CLs were isolated through differential ultracentrifugation, characterized for particle size and evaluated for antioxidant activity. Results: EXO-CLs exhibited a mean size of 93.77 +/- 12.31 nm, demonstrated permeability across the blood-brain barrier (BBB) and displayed antioxidant activity comparable to ascorbic acid. Additionally, they were found to be non-toxic, with over 80% cell viability observed in SH-SY5Y cells. Conclusion: The study proposes that EXO-CLs could serve as an effective treatment for neurodegenerative diseases. This suggests a promising approach for targeted interventions in brain-related disorders, owing to the antioxidant properties and BBB permeability exhibited by EXO-CLs.
引用
收藏
页码：507 / 519
页数：13
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