Efficacy and safety of trastuzumab deruxtecan in patients with HER2-expressing solid tumors: results from the cervical, endometrial, and ovarian cancer cohorts of the destiny-PanTumor02 study

被引:0
|
作者
Lee, Jung-Yun [1 ]
Makker, Vicky [2 ,3 ]
Manso, Luis [4 ]
Gonzalez-Martin, Antonio [5 ,6 ]
Lugowska, Iwona [7 ,8 ,9 ]
Lorusso, Domenica [10 ,11 ]
Banerjee, Susana [12 ,13 ]
Liao, John [14 ]
Lu, Chien-Hsing [15 ]
Prasongsook, Naiyarat [16 ]
Melichar, Bohuslav [17 ]
Chen, Kai [18 ]
Mcewen, Robert [19 ]
Michelini, Flavia [20 ]
Puvvada, Soham [19 ]
Meric-Bernstam, Funda [21 ]
Oaknin, Ana [22 ]
机构
[1] Yonsei Univ, Coll Med, Obstet & Gynecol, Seoul, South Korea
[2] Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY USA
[3] Weill Cornell Med Coll, Dept Med, New York, NY USA
[4] Hosp Univ 12 Octubre, Dept Med Oncol, Madrid, Spain
[5] Clin Univ Navarra, Canc Ctr, Med Oncol Dept, Madrid, Spain
[6] Programme Solid Tumours Cima, Madrid, Spain
[7] Maria Sklodowska Curie Natl Res Inst, Warsaw, Poland
[8] Oncol Ctr, Early Phase Clin Trials Unit, Warsaw, Poland
[9] Dept Soft Tissue bone Sarcoma & Melanoma, Warsaw, Poland
[10] Fdn Policlin Gemelli, Rome, Italy
[11] Univ Cattolica Sacro Cuore, Div Gynecol Oncol, Rome, Italy
[12] Royal Marsden NHS Fdn Trust, London, England
[13] Inst Canc Res, Gynaecol Unit, London, England
[14] Univ Washington, Div Gynecol Oncol, Seattle, WA USA
[15] Taichung Vet Gen Hosp, Dept Obstet & Gynecol, Taichung, Taiwan
[16] Phramongkutklao Hosp, Med Oncol Unit, Bangkok, Thailand
[17] Palacky Univ, Univ Hosp, Med Sch, Dept Oncol, Olomouc, Czech Republic
[18] AstraZeneca, Oncol Randd, Gaithersburg, MD USA
[19] AstraZeneca, Oncol Randd, Cambridge, England
[20] AstraZeneca, Translat Med, Oncol Randd, Waltham, MA USA
[21] Univ Texas MD Anderson Canc Ctr, Dept Invest Canc Therapeut, Houston, TX USA
[22] Hosp Univ Vall dHebron, Vall dHebron Inst Oncol VHIO, Gynaecol Canc Programme, Vall dHebron Barcelona Hosp Campus, Barcelona, Spain
关键词
D O I
10.1136/ijgc-2023-IGCS.7
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
PO007LBA
引用
收藏
页码:A6 / A7
页数:2
相关论文
共 50 条
  • [1] Efficacy and Safety of Trastuzumab Deruxtecan in Patients With HER2-Expressing Solid Tumors: Primary Results From the DESTINY-PanTumor02 Phase II Trial
    Meric-Bernstam, Funda
    Makker, Vicky
    Oaknin, Ana
    Oh, Do-Youn
    Banerjee, Susana
    Gonzalez-Martin, Antonio
    Jung, Kyung Hae
    Lugowska, Iwona
    Manso, Luis
    Manzano, Aranzazu
    Melichar, Bohuslav
    Siena, Salvatore
    Stroyakovskiy, Daniil
    Fielding, Anitra
    Ma, Yan
    Puvvada, Soham
    Shire, Norah
    Lee, Jung-Yun
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2024, 42 (01) : 47 - +
  • [2] Efficacy and safety of trastuzumab deruxtecan (T-DXd) in patients (pts) with HER2-expressing solid tumors: DESTINY-PanTumor02 (DP-02) interim results.
    Meric-Bernstam, Funda
    Makker, Vicky
    Oaknin, Ana
    Oh, Do-Youn
    Banerjee, Susana N.
    Martin, Antonio Gonzalez
    Jung, Kyung Hae
    Lugowska, Iwona A.
    Manso, Luis
    Manzano, Aranzazu
    Melichar, Bohuslav
    Siena, Salvatore
    Stroyakovskiy, Daniil
    Anoka, Chiedozie
    Ma, Yan
    Puvvada, Soham D.
    Lee, Jung-Yun
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2023, 41 (17_SUPPL) : LBA3000 - LBA3000
  • [3] Efficacy and safety of trastuzumab deruxtecan (T-DXd) in patients (pts) with HER2-expressing solid tumors: Results from the bladder cohort of the DESTINY-PanTumor02 (DP-02) study
    Wysocki, Piotr Jan
    Jung, Kyung Hae
    Oh, Do-Youn
    Doroshow, Deborah Blythe
    Artamonova, Elena
    Mammatas, Lemonitsa
    Su, Po-Jung
    Moiseyenko, Vladimir
    Penkov, Konstantin
    Stroyakovskiy, Daniil
    Bartolome, Jorge
    Siena, Salvatore
    Fielding, Anitra
    Jung, Lindsey
    Michelini, Flavia
    Puvvada, Soham D.
    Makker, Vicky
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2024, 42 (16)
  • [4] Efficacy of Trastuzumab Deruxtecan in HER2-Expressing Solid Tumors by Enrollment HER2 IHC Status: Post Hoc Analysis of DESTINY-PanTumor02
    Oaknin, Ana
    Lee, Jung-Yun
    Makker, Vicky
    Oh, Do-Youn
    Banerjee, Susana
    Gonzalez-Martin, Antonio
    Jung, Kyung Hae
    Lugowska, Iwona
    Manso, Luis
    Manzano, Aranzazu
    Melichar, Bohuslav
    Siena, Salvatore
    Stroyakovskiy, Daniil
    Fielding, Anitra
    Puvvada, Soham
    Smith, Ann
    Meric-Bernstam, Funda
    [J]. ADVANCES IN THERAPY, 2024,
  • [5] Trastuzumab deruxtecan (T-DXd) for pretreated patients (pts) with HER2-expressing solid tumors: Primary analysis from the DESTINY-PanTumor02 (DP-02) study
    Meric-Bernstam, F.
    Makker, V.
    Oaknin, A.
    Oh, D. Y.
    Banerjee, S.
    Martin, A. Gonzalez
    Jung, K. H.
    Lugowska, I.
    Manso, L. M.
    Manzano, A.
    Melichar, B.
    Siena, S.
    Stroyakovskiy, D.
    Fielding, A.
    Ma, Y.
    Puvvada, S. D.
    Lee, J. Y.
    [J]. ANNALS OF ONCOLOGY, 2023, 34 : S1273 - S1274
  • [6] Trastuzumab deruxtecan (T-DXd) for pretreated patients (pts) with HER2-expressing solid tumors: Primary analysis from the DESTINY-PanTumor02 (DP-02) study
    Oh, D-Y.
    Meric-Bernstam, F.
    Makker, V.
    Oaknin, A.
    Banerjee, S.
    Gonzalez Martin, A.
    Jung, K. H.
    Lugowska, I.
    Manso, L. M.
    Manzano, A.
    Melichar, B.
    Siena, S.
    Stroyakovskiy, D.
    Fielding, A.
    Ma, Y.
    Puvvada, S. D.
    Lee, J-Y.
    [J]. ANNALS OF ONCOLOGY, 2023, 34 : S1494 - S1495
  • [7] Trastuzumab deruxtecan (T-DXd) in patients (pts) with HER2-expressing head and neck tumors: Outcomes from DESTINY-PanTumor02 (DP-02)
    Meric-Bernstam, Funda
    Kim, Seung Tae
    Parinyanitikul, Napa
    Moreno, Alberto
    Lin, Chia-Chi
    Gornastolev, Dmitry
    Chindaprasirt, Jarin
    Lugowska, Iwona A.
    Stroyakovskiy, Daniil
    Jassem, Jacek
    Harrison, Michelle L.
    Ostwal, Vikas S.
    Michelini, Flavia
    Jung, Lindsey
    Kuptsova-Clarkson, Nataliya
    Puvvada, Soham D.
    Gan, Hui Kong
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2024, 42 (16)
  • [8] Efficacy and safety of trastuzumab deruxtecan (T-DXd) in patients (pts) with HER2expressing solid tumors: DESTINY-PanTumor02 (DP-02) interim results.
    Meric-Bernstam, Funda
    Makker, Vicky
    Oaknin, Ana
    Oh, Do-Youn
    Banerjee, Susana N.
    Martin, Antonio Gonzalez
    Jung, Kyung Hae
    Lugowska, Iwona A.
    Manso, Luis
    Manzano, Aranzazu
    Melichar, Bohuslav
    Siena, Salvatore
    Stroyakovskiy, Daniil
    Anoka, Chiedozie
    Ma, Yan
    Puvvada, Soham D.
    Lee, Jung-Yun
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2023, 41 (17)
  • [9] A phase II, multicenter, open-label study evaluating trastuzumab deruxtecan (T-DXd) for the treatment of select HER2-expressing solid tumors (DESTINY-PanTumor02)
    Meric-Bernstam, F.
    Anoka, C.
    Dobrowolska, A.
    Chaudhry, A.
    Rowbottom, J.
    Gustavson, M.
    Puvvada, S.
    [J]. ANNALS OF ONCOLOGY, 2021, 32 : S1253 - S1254
  • [10] DESTINY-PanTumor02 study of trastuzumab deruxtecan (T-DXd) in patients (pts) with HER2-expressing solid tumors: Exploratory biomarker analyses of HER2 expression and gene amplification in tissue and plasma
    Makker, V.
    Lee, J-Y.
    Oh, D-Y.
    Oaknin, A.
    Puvvada, S. D.
    Cecchi, F.
    Mcewen, R.
    Michelini, F.
    Meric-Bernstam, F.
    [J]. ANNALS OF ONCOLOGY, 2023, 34 : S239 - S240