APOE loss of function: A genetic shield against Alzheimer's disease

被引：1

作者：

Tate, Mason D. ^{[1
,2
]}

Karahan, Hande ^{[1
,3
]}

Kim, Jungsu ^{[1
,2
,3
]}

机构：

[1] Indiana Univ Sch Med, Stark Neurosci Res Inst, Indianapolis, IN 46202 USA

[2] Indiana Univ Sch Med, Med Neurosci Grad Program, Indianapolis, IN 46202 USA

[3] Indiana Univ Sch Med, Dept Med & Mol Genet, Indianapolis, IN 46202 USA

来源：

NEURON | 2024年 / 112卷 / 07期

关键词：

REDUCES AMYLOID DEPOSITION; MOUSE MODEL;

D O I：

10.1016/j.neuron.2024.03.003

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In this issue of Neuron , Chemparathy et al. provide human genetics data suggesting that APOE loss -of-function mutations may confer resistance to Alzheimer's disease (AD) without compromising longevity. These data strongly support the APOE toxic gain -of -function hypothesis for AD.

引用

页码：1033 / 1035

页数：3

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