Investigation of particle flow effects in slug flow crystallization using the multiscale computational fluid dynamics simulation

This article discusses the development of a new computational fluid dynamics (CFD) model, the MVP (MP-PIC coupled with VOF and PBE) method, which predicts the slug flow crystallization phenomenon. The model is capable of predicting the flow of gas -liquid-solid phases and the associated chemical and particle changes. The MVP model is validated through a comparison with an experimental study on LAM (L-asparagine monohydrate) crystallization, and the results demonstrate its ability to accurately predict the three-phase fluid flow with particle size variation. In particular, we have been able to predict the effect of slug length change on particle mixing and predict hydrodynamic factors such as the particle streamlines and the circulation number of the particle phase via case studies. Overall, the MVP model is expected to offer a new way to accurately predict slug flow crystallization and provide valuable information for the process intensification of crystallization.