Systemic and CNS distributional pharmacokinetics of WSD0628, a novel radiosensitizer: Implications for the treatment of brain tumors

被引:0
|
作者
Rathi, Sneha
Mladek, Ann
Xue, Zhiyi
Oh, Ju-Hee
Zhang, Wenjuan
Zhang, Wenqiu
Le, Jiayan
Sarkaria, Jann S.
Elmquist, William F.
机构
关键词
D O I
10.1158/1538-7445.BRAIN23-B028
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
B028
引用
收藏
页数:2
相关论文
共 8 条
  • [1] PHARMACOKINETICS AND CNS DISTRIBUTION OF A NOVEL ATM INHIBITOR, WSD0628, FOR THE TREATMENT OF BRAIN TUMORS
    Rathi, Sneha
    Oh, Ju-Hee
    Sarkaria, Jann
    Elmquist, William F.
    NEURO-ONCOLOGY, 2022, 24 : 95 - 95
  • [2] Preclinical Systemic Pharmacokinetics, Dose Proportionality, and Central Nervous System Distribution of the ATM Inhibitor WSD0628, a Novel Radiosensitizer for the Treatment of Brain Tumors
    Rathi, Sneha
    Oh, Ju-Hee
    Zhang, Wenjuan
    Mladek, Ann C.
    Garcia, Darwin A.
    Xue, Zhiyi
    Burgenske, Danielle M.
    Zhang, Wenqiu
    Le, Jiayan
    Zhong, Wei
    Sarkaria, Jann N.
    Elmquist, William F.
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2024, 390 (02): : 260 - 275
  • [3] WSD0628: A BRAIN PENETRABLE ATM INHIBITOR AS A RADIOSENSITIZER FOR THE TREATMENT OF GBM AND METASTATIC CNS TUMOR
    Zhong, Wei
    Liu, Lily
    Sun, Claire
    Mu, Zhihua
    NEURO-ONCOLOGY, 2021, 23 : 79 - 79
  • [4] The radiosensitizing effects of the novel brain penetrant and potent ATM inhibitor WSD0628 in glioblastoma and melanoma patient derived xenografts
    Xue, Zhiyi
    Mladek, Ann C.
    Rathi, Sneha
    Burgenske, Danielle M.
    Gupta, Shiv K.
    Carlson, Brett L.
    Hu, Zeng
    Ott, Lauren L.
    Bakken, Katrina K.
    Vaubel, Rachael A.
    Elimquist, William F.
    Zhong, Wei
    Sarkaria, Jann N.
    MOLECULAR CANCER THERAPEUTICS, 2023, 22 (12)
  • [5] WSD1227: A novel, oral bioavailable, brain penetrable and reversible VEGFR inhibitor for the treatment of primary and metastatic brain tumors
    Zhang, Jinqiang
    Zhong, Wei
    Mu, Zhihua
    Sun, Claire
    CANCER RESEARCH, 2018, 78 (13)
  • [6] WSD0922: A novel, oral bioavailable, brain penetrable and reversible EGFRm plus inhibitor for the treatment of primary and metastatic brain tumors
    Zhong, Wei
    Zhang, Jinqiang
    Mu, Zhihua
    Sun, Claire
    CANCER RESEARCH, 2018, 78 (13)
  • [7] Beyond the Blood: Brain Barrier: The Importance of Central Nervous System (CNS) Pharmacokinetics for the Treatment of CNS Tumors, Including Diffuse Intrinsic Pontine Glioma
    Warren, Katherine Elizabeth
    FRONTIERS IN ONCOLOGY, 2018, 8
  • [8] A potential role of pemetrexed (PMTX) for the treatment (Tx) of thymidylate synthase (TS) negative primary brain tumors and systemic malignancies with CNS metastasis.
    Kim, Lyndon J.
    Evans, James J.
    Judy, Kevin D.
    Farrell, Christopher
    Andrews, David W.
    JOURNAL OF CLINICAL ONCOLOGY, 2017, 35