Emerging role of gut microbiota in autoimmune diseases

被引：1
|
作者：
Wang, Xinyi [1 ,2 ]
Yuan, Wei [3 ]
Yang, Chunjuan [4 ,5 ]
Wang, Zhangxue [5 ]
Zhang, Jin [5 ]
Xu, Donghua [4 ,5 ]
Sun, Xicai [6 ]
Sun, Wenchang [4 ]
机构：
[1] Shandong First Med Univ, Sch Clin & Basic Med Sci, Jinan, Peoples R China
[2] Shandong Acad Med Sci, Jinan, Peoples R China
[3] Shandong Second Med Univ, Dept Radiat Oncol, Affiliated Hosp 1, Weifang, Peoples R China
[4] Shandong Second Med Univ, Affiliated Hosp 1, Dept Cent Lab, Weifang, Peoples R China
[5] Shandong Second Med Univ, Dept Rheumatol, Affiliated Hosp 1, Weifang, Peoples R China
[6] Shandong Second Med Univ, Dept Hosp Off, Affiliated Hosp 1, Weifang, Peoples R China
来源：
FRONTIERS IN IMMUNOLOGY | 2024年 / 15卷
基金：
中国国家自然科学基金;
关键词：
autoimmune disease; homeostasis; gut microbiota; probiotics; microbiome; CHAIN FATTY-ACIDS; REGULATORY T-CELLS; COLLAGEN-INDUCED ARTHRITIS; DIETARY FIBER; LACTOBACILLUS-RHAMNOSUS; INTESTINAL MICROBIOTA; ENTEROCOCCUS-FAECIUM; ULCERATIVE-COLITIS; HUMORAL IMMUNITY; B-CELLS;
D O I：
10.3389/fimmu.2024.1365554
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Accumulating studies have indicated that the gut microbiota plays a pivotal role in the onset of autoimmune diseases by engaging in complex interactions with the host. This review aims to provide a comprehensive overview of the existing literatures concerning the relationship between the gut microbiota and autoimmune diseases, shedding light on the complex interplay between the gut microbiota, the host and the immune system. Furthermore, we aim to summarize the impacts and potential mechanisms that underlie the interactions between the gut microbiota and the host in autoimmune diseases, primarily focusing on systemic lupus erythematosus, rheumatoid arthritis, Sj & ouml;gren's syndrome, type 1 diabetes mellitus, ulcerative colitis and psoriasis. The present review will emphasize the clinical significance and potential applications of interventions based on the gut microbiota as innovative adjunctive therapies for autoimmune diseases.
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页数：14
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