Long-Term Follow-Up of Phase I Trial of Oncolytic Adenovirus-Mediated Cytotoxic and Interleukin-12 Gene Therapy for Treatment of Metastatic Pancreatic Cancer

被引:2
|
作者
Bhatnagar, Aseem Rai [1 ]
Siddiqui, Farzan [1 ]
Khan, Gazala [2 ]
Pompa, Robert [3 ]
Kwon, David [4 ]
Nyati, Shyam [1 ]
机构
[1] Henry Ford Hosp, Dept Radiat Oncol, Detroit, MI 48202 USA
[2] Henry Ford Hosp, Dept Med Oncol, Detroit, MI 48202 USA
[3] Henry Ford Hosp, Dept Gastroenterol, Detroit, MI 48202 USA
[4] Henry Ford Hosp, Dept Surg, Detroit, MI 48202 USA
关键词
metastatic pancreatic cancer; oncolytic adenovirus; overall survival;
D O I
10.3390/biomedicines12051065
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The long-term follow-up findings of the phase I trial evaluating the efficacy of oncolytic adenovirus-mediated cytotoxic and interleukin-12 gene therapy in metastatic pancreatic cancer (mPC) seem very promising. The study employed a replication-competent Adenovector in combination with chemotherapy in a dose-escalation format. The trial demonstrated a clinically meaningful median overall survival (OS) benefit, with patients in the highest dose cohort exhibiting an impressive median OS of 18.4 months. This contrasts starkly with patients receiving lower doses who experienced a median OS of 4.8 and 3.5 months, respectively. Remarkably, subject number 10, who received the highest dose, demonstrated an extraordinary survival of 59.1 months, presenting a compelling case for further exploration. Additionally, this patient displayed complete responses in lung and liver metastases, a rare occurrence in mPC treatment. Statistical analyses supported the observed survival benefit. The unprecedented OS results emphasize the potential of this treatment strategy and pave the way for future investigations into this promising gene therapy approach.
引用
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页数:7
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