Approach to Immune-mediated Ocular Diseases

Immune -mediated keratitis (IMMK) is an umbrella term used to describe idiopathic, presumed noninfectious inflammation of the cornea. The disease is most commonly nonulcerative and characterized by corneal opacification (infiltrate, fibrosis, and edema) and vascularization, the severity of which can vary drastically . No breed predispositions have been described, and the disease is more often unilateral though may be bilateral. 1,2 IMMK is generally classified based on the affected layer(s) of the cornea, including epithelial, superficial stromal, midstromal, and endothelial ( Fig. 1 ). Epithelial, superficial