Syk inhibition suppresses NLRP3 inflammasome activation in platelets from sickle cell mice leading to decreased platelet secretion, aggregation, spreading, and in vitro thrombus formation

被引：0
|
作者：
Vogel, Sebastian [1 ]
Kamimura, Sayuri [1 ]
Smith, Meghann L. [1 ]
Almeida, Luis E. F. [1 ]
Cui, Xizhong [2 ]
Combs, Christian A. [3 ]
Quezado, Zenaide M. N. [1 ,4 ]
机构：
[1] NIH, Dept Perioperat Med, Clin Ctr, Bethesda, MD USA
[2] NIH, Crit Care Med Dept, Clin Ctr, Bethesda, MD USA
[3] NHLBI, Light Microscopy Core, NIH, Bethesda, MD USA
[4] NIH, Clin Ctr, 10 Ctr Dr,Bldg 10, Bethesda, MD 20814 USA
来源：
THROMBOSIS RESEARCH | 2024年 / 237卷
基金：
美国国家卫生研究院;
关键词：
NLRP3; inflammasome; Fostamatinib; Platelets; Sickle cell disease; TYROSINE KINASE; GPVI;
D O I：
10.1016/j.thromres.2024.03.020
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：18 / 22
页数：5
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