Plasma biomarkers of Alzheimer's disease in the continuum of dementia with Lewy bodies

被引：0

作者：

Diaz-Galvan, Patricia ^{[1
]}

Przybelski, Scott A. ^{[2
]}

Algeciras-Schimnich, Alicia ^{[3
]}

Figdore, Dan J. ^{[3
]}

Lesnick, Timothy G. ^{[2
]}

Schwarz, Christopher G. ^{[1
]}

Senjem, Matthew L. ^{[1
,4
]}

Gunter, Jeffrey L. ^{[1
]}

Jack, Clifford R., Jr. ^{[1
]}

Hmin, Paul ^{[1
]}

Jain, Manoj K.

Miyagawa, Toji ^{[5
]}

Forsberg, Leah K. ^{[5
]}

Fields, Julie A. ^{[6
]}

Savica, Rodolfo ^{[5
]}

Graff-Radford, Jonathan ^{[5
]}

Ramanan, Vijay K. ^{[5
]}

Jones, David T. ^{[5
]}

Botha, Hugo ^{[5
]}

St Louis, Erik K. ^{[7
,8
,9
]}

Knopman, David S. ^{[5
]}

Graff-Radford, Neill R. ^{[10
]}

Ferman, Tanis J. ^{[11
]}

Petersen, Ronald C. ^{[2
,5
]}

Lowe, Val J. ^{[1
]}

Boeve, Bradley F. ^{[5
]}

Kantarci, Kejal ^{[1
]}

机构：

[1] Mayo Clin, Dept Radiol, Imaging Res Bldg,Crossrd Dr SW, Rochester, MN 55902 USA

[2] Mayo Clin, Dept Quantitat Hlth Sci, Rochester, MN USA

[3] Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA

[4] Mayo Clin, Dept Radiol, Jacksonville, FL USA

[5] Mayo Clin, Dept Neurol, Rochester, MN USA

[6] Mayo Clin, Dept Psychiat & Psychol, Rochester, MN USA

[7] Mayo Clin, Mayo Ctr Sleep Med, Rochester, MN USA

[8] Mayo Clin Southwest Wisconsin, Dept Neurol, La Crosse, WI USA

[9] Mayo Clin Southwest Wisconsin, Clin & Translat Res, La Crosse, WI USA

[10] Mayo Clin, Dept Neurol, Jacksonville, FL USA

[11] Mayo Clin, Dept Psychiat & Psychol, Jacksonville, FL USA

来源：

ALZHEIMERS & DEMENTIA | 2024年 / 20卷 / 04期

基金：

美国国家卫生研究院;

关键词：

Alzheimer's disease; Lewy body; mild cognitive impairment; PET biomarkers; plasma biomarkers; REM sleep behavior disorder; TAU; PERFORMANCE; DIAGNOSIS; DLB;

D O I：

暂无

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

INTRODUCTION: Patients with dementia with Lewy bodies (DLB) may have Alzheimers disease (AD) pathology that can be detected by plasma biomarkers. Our objective was to evaluate plasma biomarkers of ADand their associationwith positron emission tomography (PET) biomarkers of amyloid and tau deposition in the continuum of DLB, starting from prodromal stages of the disease. METHODS: The cohort included patients with isolated rapid eye movement (REM) sleep behavior disorder (iRBD), mild cognitive impairment with Lewy bodies (MCI-LB), or DLB, with a concurrent blood draw and PET scans. RESULTS: Abnormal levels of plasma glial fibrillary acidic protein (GFAP) were found at the prodromal stage of MCI-LB in association with increased amyloid PET. Abnormal levels of plasma phosphorylated tau (p-tau)-181 and neurofilament light (NfL) were found at the DLB stage. Plasma p-tau-181 showed the highest accuracy in detecting abnormal amyloid and tau PET in patients with DLB. DISCUSSION: The range of AD co-pathology can be detected with plasma biomarkers in the DLB continuum, particularly with plasma p-tau-181 and GFAP.

引用

页码：2485 / 2496

页数：12

共 50 条

[1] Plasma biomarkers of Alzheimer's disease in the continuum of dementia with Lewy bodies
Diaz-Galvan, Patricia
Przybelski, Scott A.
Algeciras-Schimnich, Alicia
Figdore, Dan J.
Lesnick, Timothy G.
Schwarz, Christopher G.
Senjem, Matthew L.
Gunter, Jeffrey L.
Jack, Clifford R., Jr.
Hmin, Paul
Jain, Manoj K.
Miyagawa, Toji
Forsberg, Leah K.
Fields, Julie A.
Savica, Rodolfo
Graff-Radford, Jonathan
Ramanan, Vijay K.
Jones, David T.
Botha, Hugo
St Louis, Erik K.
Knopman, David S.
Graff-Radford, Neill R.
Ferman, Tanis J.
Petersen, Ronald C.
Lowe, Val J.
Boeve, Bradley F.
Kantarci, Kejal
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