Expression of CD44 and SALL4 in leukoplakia and oral squamous cell carcinoma

被引：0
|
作者：
Sahoo, Pravudeva [1 ]
Kumar, Harish [2 ]
Panda, Abikshyeet [2 ]
Dash, Kailash Chandra [2 ]
Bhuyian, Lipsa [2 ]
Raghuvanshi, Malvika [2 ]
Panda, Baisali [2 ]
机构：
[1] Bhubaneswar ENT & Dent Care, Bhubaneswar, Odisha, India
[2] Kalinga Inst Dent Sci, Dept Oral & Maxillofacial Pathol, Campus 5, Bhubaneswar 751024, Odisha, India
来源：
JOURNAL OF PHARMACY AND BIOALLIED SCIENCES | 2024年 / 16卷
关键词：
CD44; leukoplakia; oral cancer; SALL4;
D O I：
10.4103/jpbs.jpbs_1178_23
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
CD44 and SALL4 are markers of stemness and expressed in cancer stem cells (CSCs). Their deregulated expression was seen in various tumors and has been correlated with clinical severity. We evaluated immunohistochemical expression of CD44 and SALL4 in leukoplakia and oral squamous cell carcinoma (OSCC). CD44 was expressed in all the cases of leukoplakia and Its expression correlated with severity of the dysplasia in leukoplakia but varied with differentiation in OSCC. SALL4 did not express in leukoplakia. Its expression was varied in OSCC cases. We opine that CD44 expression is consistent with the progression of dysplasia in leukoplakia and differentiation in OSCC.
引用
收藏
页码：1761 / 1763
页数：3
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