Prolonged half-life and sustained inhibition of key inflammatory biomarkers: a phase 1 study of APG777, a high-affinity humanized IgG1 monoclonal antibody targeting IL-13

被引：0

作者：

Lim, Xiu Qin ^{[1
]}

Winter, Erica ^{[2
]}

Nograles, Kristine ^{[2
]}

Thankamony, Sai ^{[2
]}

Dillinger, Lukas ^{[2
]}

Dambkowski, Carl ^{[2
]}

机构：

[1] CMAX Clin Res, Adelaide, SA, Australia

[2] Apogee Therapeut Inc, Waltham, MA USA

来源：

BRITISH JOURNAL OF DERMATOLOGY | 2024年 / 191卷

关键词：

APG777; biologic; therapy;

D O I：

10.1093/bjd/ljae266.085

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

711

引用

页码：88 / 88

页数：1

共 6 条

[1] Prolonged half-life and sustained inhibition of key inflammatory biomarkers: a phase 1 study of APG777, a high-affinity humanized IgG1 monoclonal antibody targeting IL-13
Lim, X. Q.
Winter, E.
Nograles, K.
Thankamony, S.
Dillinger, L.
Dambkowski, C.
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2024, 144 (08) : S165 - S165
[2] APG777, a high-affinity humanized IgG1 monoclonal antibody targeting IL-13, demonstrates prolonged half-life and pSTAT6 inhibition in non-human primates
Zhu, E.
Oh, J.
Dillinger, L.
Shaheen, H.
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2024, 144 (08) : S132 - S132
[3] APG777, ANTI-IL-13 MONOCLONAL ANTIBODY, DEMONSTRATES EXTENDED HALF-LIFE AND SUSTAINED INHIBITION OF TYPE 2 INFLAMMATORY BIOMARKERS
Lim, X.
Winter, E.
Nograles, K.
Thankamony, S.
Dillinger, L.
Dambkowski, C.
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 2024, 133 (06) : S54 - S54
[4] APG808, A High-Affinity Fully Human IgG1 Monoclonal Antibody Targeting IL-4Rα, Demonstrates Prolonged Half-Life in Non-Human Primates
Dillinger, L.
Dabora, R.
Shaheen, H.
Oh, J.
Zhu, E.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2024, 209
[5] APG808, A Fully Human Monoclonal IgG1 Antibody, Binds to IL-4Rα With High Affinity and Blocks IL-13 and IL-4 Mediated Signalling in Multiple In Vitro Assays
Dillinger, L.
Dabora, R.
Shaheen, H.
Oh, J.
Zhu, E.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2024, 209
[6] A phase 1 open-label, single-dose, dose-escalation study of Mdx-1100, a high-affinity, neutralizing, fully human Igg1κ anti-CXCL10 (Ip10) monoclonal antibody, in ulcerative colitis
Hardi, Robert
Mayer, Lloyd
Targan, Stephan R.
Yellin, Michael
Cardarelli, Pina M.
Das, Kiron M.
GASTROENTEROLOGY, 2008, 134 (04) : A99 - A100

← 1 →