Depression as a Risk Factor for Dementia: A Meta-Analysis

被引:2
|
作者
Fernandez, Roberto Fernandez [1 ]
Martin, Javier Ibias [2 ]
Anton, Maria Araceli Macia [2 ]
机构
[1] Infanta Cristina Univ Hosp, Dept Psychiat, Madrid, Spain
[2] Natl Distance Educ Univ UNED, Dept Methodol Behav Sci, Madrid 28015, Spain
关键词
LATE-LIFE DEPRESSION; MILD COGNITIVE IMPAIRMENT; SUBSEQUENT DEMENTIA; INCIDENT DEMENTIA; MAJOR DEPRESSION; ALZHEIMERS-DISEASE; SYMPTOMS; ONSET; ASSOCIATION; HISTORY;
D O I
10.1176/appi.neuropsych.20230043
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Dementia is a syndrome characterized by the deterioration of cognitive function beyond what is expected. The increased risk of developing this syndrome resulting from established modifiable risk factors, such as depressive episodes, is currently a subject of interest. The aim of this study was to review the scientific evidence that addresses the relationship between depression and dementia. A bibliographic search of the PubMed and PsycInfo databases for articles published over the past 20 years was conducted with the following medical subject heading terms: depression or depressive, dementia, and incidence or cohort studies. After articles meeting the inclusion criteria were selected, relevant moderating variables were grouped as sample characteristics, methodological characteristics, extrinsic characteristics, and outcome variables. The 26 selected studies resulted in a sample comprising 1,760,262 individuals. Statistical analysis revealed a pooled relative risk for the development of dementia of 1.82 (95% CI=1.62-2.06). The primary variables evaluated were the diagnostic methods for depression and dementia and the presence of depression. Other variables, such as mean age, methodological quality of each study, follow-up time, and publication year, were also evaluated. Age was statistically but not clinically significant. No relevant publication bias or alterations in the results were found when accounting for the quality of the studies. It is recommended that new moderating variables be evaluated or that existing variables be reformulated in future studies.
引用
收藏
页码:101 / 109
页数:9
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