Remdesivir treatment does not reduce viral titers in patients with COVID-19

被引：0
|
作者：
Faghihi, Isa [1 ]
Yan, Victoria C. [1 ]
机构：
[1] Univ Texas Southwestern Med Ctr, Dallas, TX 75390 USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2024年 / 68卷 / 08期
关键词：
remdesivir; SARS-CoV-2; COVID-19; pharmacology; pharmacodynamics; antivirals; drug development;
D O I：
10.1128/aac.00856-24
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The relationship (or lack thereof) between the clinical activity of remdesivir and its ability to reduce viral titers in patients with COVID-19 has not been fully delineated. There is a misconception that remdesivir was FDA-approved for COVID-19 due to its ability to reduce viral titers. Here, we analyze all clinical studies of remedesivir in COVID-19 that quantifed SARS-CoV-2 titers. As of 28 June 2024, we show there is no significant decrease in SARS-CoV-2 viral titers in patients treted with remdesivir compared to placebo controls.
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页数：4
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