A type of brain-targeting nano-formulation and its anti-tumour effect in paediatric brain tumour cells

被引：0
|
作者：
Tian, Xin [1 ,2 ,3 ]
Shi, Taoxiang [1 ,2 ]
Fu, Shiyang [1 ,2 ]
Liu, Zheda [1 ,2 ]
You, Yalan [1 ,2 ,3 ]
Chen, Keke [1 ,2 ,3 ]
Yao, Anqi [1 ,2 ,3 ]
Zhu, Chengguang [1 ,2 ,3 ]
Zeng, Minhui [1 ,2 ,3 ]
Tang, Wenfang [1 ,2 ,3 ]
Tao, Xiaojun [1 ,2 ]
He, Xiangling [1 ,2 ,3 ]
机构：
[1] Hunan Normal Univ, Hunan Prov Peoples Hosp, Affiliated Hosp 1, Childrens Med Ctr,Dept Pediat Hematol & Oncol, Changsha 410081, Peoples R China
[2] Hunan Normal Univ, Sch Med, Changsha 410081, Peoples R China
[3] Childrens Med Ctr, Dept Hematol & Oncol, Changsha, Hunan, Peoples R China
来源：
MATERIALS TECHNOLOGY | 2024年 / 39卷 / 01期
关键词：
Pediatric brain tumours; cholesterol; pullulan; Tween; 80; vincristine; DELIVERY; NANOPARTICLES; VINCRISTINE; BLOOD; VESSELS; SYSTEM;
D O I：
10.1080/10667857.2024.2352675
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
In this study, we grafted cholesterol with pullulan to synthesize hydrophobic pullulan(CHP). Three CHP polymers (CHP1, CHP2, and CHP3), with different degrees of substitution were designed by changing the feed ratio of cholesterol to pullulan. The 1H-NMR results showed that the hydrophobic substitutability of CHP1, CHP2, and CHP3 were calculated to be 8.26%, 5.67%, and 3.52%, respectively. The sizes of CHP1 NPs, CHP2 NPs, and CHP3 NPs were (118 +/- 7.9), (123 +/- 4.7) and (158 +/- 9.3) nm, respectively. The CHP NPs embedded with VCR and adsorbed Tween 80 (CHPT@VCR NPs). The results of microscale thermal imaging (MST) testing indicated the CHP-1 NPs with the highest degree of cholesterol substitution possessed the highest adsorption capacity for Tween 80. In vitro pharmacological studies were conducted in SJ-GBM2 cells, the results showed that the tumor cells inhibition rate and the cellular uptake rate of CHPT@VCR-1 NPs were the highest compared with CHPT@VCR-2 NPs and CHPT@VCR-3 NPs.
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页数：14
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