Risk Factors and Prognostic Factors in GBC

被引:1
|
作者
Tirca, Luiza [1 ]
Savin, Catalin [1 ]
Stroescu, Cezar [2 ,3 ]
Balescu, Irina [1 ]
Petrea, Sorin [2 ,4 ]
Diaconu, Camelia [5 ,6 ]
Gaspar, Bogdan [2 ,7 ]
Pop, Lucian [8 ,9 ]
Varlas, Valentin [8 ,10 ]
Hasegan, Adrian [11 ]
Martac, Cristina [12 ]
Bolca, Ciprian [13 ,14 ,15 ]
Stoian, Marilena [6 ,16 ]
Zgura, Anca [17 ,18 ]
Gorecki, Gabriel Petre [19 ,20 ]
Bacalbasa, Nicolae [2 ,3 ]
机构
[1] Carol Davila Univ Med & Pharm, Dept Visceral Surg, Bucharest 050474, Romania
[2] Carol Davila Univ Med & Pharm, Dept Surg, Bucharest 050474, Romania
[3] Fundeni Clin Inst, Ctr Excellence Translat Med, Dept Visceral Surg, Bucharest 022336, Romania
[4] Ion Cantacuzino Clin Hosp, Dept Surg, Bucharest 020026, Romania
[5] Floreasca Clin Emergency Hosp, Dept Internal Med, Bucharest 014453, Romania
[6] Carol Davila Univ Med & Pharm, Dept Internal Med, Bucharest 050474, Romania
[7] Floreasca Clin Emergency Hosp, Dept Visceral Surg, Bucharest 014453, Romania
[8] Carol Davila Univ Med & Pharm, Dept Obstet & Gynecol, Bucharest 050474, Romania
[9] Natl Inst Mother & Child Care Alessandrescu Rusesc, Dept Obstet & Gynecol, Bucharest 020395, Romania
[10] Filantropia Clin Hosp, Dept Obstet & Gynecol, Bucharest 011132, Romania
[11] Univ Sibiu, Sibiu Emergency Hosp, Fac Med, Dept Urol, Sibiu 550024, Romania
[12] Fundeni Clin Hosp, Dept Anesthesiol, Bucharest 022336, Romania
[13] Marius Nasta Nat Inst Pneumol, Dept Thorac Surg, Bucharest 050159, Romania
[14] Sherbrooke Univ, Fac Med & Hlth Sci, Dept Thorac Surg, Sherbrooke, PQ J1K 2R1, Canada
[15] Charles LeMoyne Hosp, Dept Thorac Surg, Longueuil, PQ J4K 0A8, Canada
[16] Dr Ion Cantacuzino Hosp, Dept Internal Med & Nephrol, Bucharest 011438, Romania
[17] Oncol Inst Prof Dr Al Trestioreanu, Dept Med Oncol, Bucharest 022328, Romania
[18] Carol Davila Univ Med & Pharm, Dept Med Oncol, Bucharest 050474, Romania
[19] CF 2 Clin Hosp, Dept Anesthesia & Intens Care, Bucharest 014256, Romania
[20] Titu Maiorescu Univ, Fac Med, Dept Anesthesia & Intens Care, Bucharest, Romania
关键词
gallbladder cancer; risk factors; prognostic factors; INCIDENTAL GALLBLADDER CANCER; RED CHILI-PEPPER; PERINEURAL INVASION; PANCREATICOBILIARY MALJUNCTION; SURGICAL-TREATMENT; SURVIVAL; BILIARY; ASSOCIATION; MANAGEMENT; CARCINOMA;
D O I
10.3390/jcm13144201
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Gallbladder cancer (GBC) is a rare entity with a poor prognosis, usually discovered late due to nonspecific symptoms; therefore, over the last years, attention has been focused on identifying the risk factors for developing this malignancy in order to provide an early diagnosis, as well as new prognostic factors in order to modulate the long-term evolution of such cases. The aim of this review is to discuss both major risk factors and prognostic factors in GBC for a better understanding and integration of relevant and currently available information. Methods: A literature search was performed using Cochrane Library, PubMed, Google Scholar, Elsevier, and Web of Science; studies published after the year of 2000, in English, were reviewed. Results: Over time, risk factors associated with the development of GBC have been identified, which outline the profile of patients with this disease. The most important prognostic factors in GBC remain TNM staging, safety margin, and R0 status, along with perineural invasion and lymphovascular invasion. Both the technique and experience of the surgeons and a pathological examination that ensures final staging are particularly important and increase the chances of survival of the patients. Conclusions: improvements in surgical techniques and pathological analyses might provide better and more consistent guidance for medical staff in the management of patients with GBC.
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页数:22
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