Association of the Complement System with Subclinical Atherosclerosis in Psoriasis: Findings from an Observational Cohort Study

被引：3

作者：

Mourino-Alvarez, Laura ^{[1
,2
]}

Perales-Sanchez, Ines ^{[1
,2
]}

Berna-Rico, Emilio ^{[3
]}

de Aragon, Carlota Abbad-Jaime ^{[3
]}

Corbacho-Alonso, Nerea ^{[1
,2
]}

Sastre-Oliva, Tamara ^{[1
,2
]}

Juarez-Alia, Cristina ^{[1
,2
]}

Ballester-Martinez, Asuncion ^{[3
]}

Castellanos-Gonzalez, Maria ^{[4
]}

Llamas-Velasco, Mar ^{[5
]}

Jaen, Pedro ^{[3
]}

Solis, Jorge ^{[6
,7
,8
]}

Fernandez-Friera, Leticia ^{[6
,7
,9
]}

Mehta, Neha N. ^{[10
]}

Gelfand, Joel M. ^{[11
,12
]}

Barderas, Maria G. ^{[12
,15
]}

Gonzalez-Cantero, Alvaro ^{[3
,13
,14
]}

机构：

[1] Hosp Nacl Paraplej, Dept Vasc Physiopathol, SESCAM, Toledo, Spain

[2] Hosp Nacl Paraplej, Dept Vasc Physiopathol, IDISCAM, Toledo, Spain

[3] Hosp Univ Ramon Y Cajal, Dept Dermatol, Inst Ramon & Cajal Invest Sanitaria, Madrid, Spain

[4] Hosp Sureste, Dept Dermatol, Madrid, Spain

[5] Hosp Univ La Princesa, Dept Dermatol, Madrid, Spain

[6] Hosp Univ Doce Octubre, Dept Cardiol, Madrid, Spain

[7] Atria Clin, Madrid, Spain

[8] Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Cardiovasc CIBE, Madrid, Spain

[9] HM Hosp Ctr Integral Enfermedades Cardiovasc HM CI, Madrid, Spain

[10] George Washington Univ, Sch Med & Hlth Sci, Dept Cardiol, Washington, DC USA

[11] Univ Penn, Perelman Sch Med, Dept Dermatol, Philadelphia, PA USA

[12] Univ Penn, Perelman Sch Med, Dept Biostat Epidemiol & Informat, Philadelphia, PA USA

[13] Univ Francisco Vitoria, Fac Med, Madrid, Spain

[14] Hosp Univ Ramon Y Cajal, Dept Dermatol, M-607,Km 9,100, Madrid 28034, Spain

[15] Hosp Nacl Paraplej, Lab Fisiopatol Vasc, SESCAM, Despacho 3,Edificio Invest 1 Planta, Toledo 45071, Spain

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2024年 / 144卷 / 05期

关键词：

Cardiovascular diseases; Inflammation; Mass spectrometry; Proteomics; Vascular biology; CORONARY-ARTERY-DISEASE; HUMAN KERATINOCYTES; CD26/DIPEPTIDYL-PEPTIDASE IV; CARDIOVASCULAR EVENTS; MYOCARDIAL-INFARCTION; SERUM-LEVELS; A-431; CELLS; FACTOR-H; ACTIVATION; RISK;

D O I：

10.1016/j.jid.2023.10.031

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Psoriasis is a chronic and inflammatory disease that affects the skin and joints and is associated with multiple comorbidities and cardiovascular risk factors. Consequently, patients with psoriasis have an increased risk of cardiovascular diseases such as atherosclerosis, a chronic pathology that shares common inflammatory and immune -response mechanisms with psoriasis, including vascular inflammation and complement activation. To better understand the relationship between atherosclerosis and psoriasis, a proteomics study followed by a bioinformatics analysis was carried out, with a subsequent validation step using ELISA and western blotting. When the plasma from patients with psoriasis alone was compared with that from patients with psoriasis and atherosclerosis, 31 proteins of interest related to the complement system and oxygen transport were identified. After the validation phase, 11 proteins appeared to define the presence of subclinical atherosclerosis in patients with psoriasis, indicating the importance of complement cascades in the development of atherosclerotic plaques in individuals with psoriasis. These results are a step forward in understanding the pathological pathways implicated in the cardiovascular risk associated with this population, which may represent an interesting starting point for developing predictive tools that improve the follow-up of these patients and design more effective therapies.

引用

页码：1075 / 1087.e2

页数：15