Prognostic Factors for Survival in Glioblastoma: A Retrospective Analysis Focused on the Role of Hemoglobin

被引:0
|
作者
Pleskacova, Zuzana [1 ]
Bartos, Michael [2 ]
Vosmikova, Hana [3 ]
Dolezal, Rafael [4 ,5 ]
Krupa, Petr [2 ]
Vitovcova, Barbora [6 ]
Kasparova, Petra [3 ]
Rudolf, Emil [6 ]
Skarkova, Veronika [6 ]
Pohankova, Denisa [1 ]
Novotna, Veronika [1 ]
Petera, Jiri [1 ]
机构
[1] Univ Hosp & Med Fac, Dept Oncol & Radiotherapy, Hradec Kralove 50005, Czech Republic
[2] Univ Hosp & Med Fac, Dept Neurosurg, Hradec Kralove 50005, Czech Republic
[3] Univ Hosp & Med Fac, Fingerland Dept Pathol, Hradec Kralove 50005, Czech Republic
[4] Univ Hosp, Biomed Res Ctr, Hradec Kralove 50005, Czech Republic
[5] Med Fac, Hradec Kralove 50005, Czech Republic
[6] Med Fac, Dept Med Biol & Genet, Hradec Kralove 50005, Czech Republic
关键词
glioblastoma; prognostic markers; HIF; hemoglobin; ADJUVANT TEMOZOLOMIDE; RADIOTHERAPY; HIF-1-ALPHA; GLIOMA; IMPACT; LEVEL; CONCOMITANT; EXPRESSION; IDH1;
D O I
10.3390/biomedicines12061210
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Background: Although several prognostic factors for survival have been identified in glioblastoma, there are numerous other potential markers (such as hemoglobin) whose role has not yet been confirmed. The aim of this study was to evaluate a wide range of potential prognostic factors, including HIF-1 alpha and hemoglobin levels, for survival in glioblastoma. A secondary aim was to determine whether hemoglobin levels were associated with HIF-1 alpha expression. Methods: A retrospective study of 136 patients treated for glioblastoma at our institution between 2012 and 2021 was performed. Cox univariate and multivariate analyses were carried out. Kaplan-Meier survival curves were generated. In addition, bivariate non-parametric correlation analyses were performed for key variables. Results: Median survival was 11.9 months (range: 0-119.4). According to the univariate analysis, 13 variables were significantly associated with survival: age, performance status, extent of surgery, tumor depth, tumor size, epilepsy, postoperative chemoradiotherapy, IDH mutations, CD44, HIF-1 alpha, HIF-1 beta, vimentin, and PDFGR. According to the multivariate regression analysis, only four variables remained significantly associated with survival: age, extent of surgery, epilepsy, and HIF-1 alpha expression. No significant association was observed between hemoglobin levels (low <120 g/L in females or <140 g/L in males vs. high >= 120 or >= 140 g/L) and survival or HIF-1 alpha/HIF-1 beta expression. Conclusions: In this retrospective study of patients with glioblastoma, four variables-age, extent of surgery, HIF-1 alpha expression, and epilepsy-were significant prognostic factors for survival. Hemoglobin levels were not significantly associated with survival or HIF-1 alpha expression. Although hypoxia is a well-recognized component of the glioblastoma microenvironment, more research is needed to understand the pathogenesis of onset tumor hypoxia and treatment implication.
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页数:11
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